GSM8077460

Dataset: gse255685 • Sample: YZ268 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 5.2%ile (↓ Low)
22,326 Genes with score > 0 Group median: 22,375 • 3.4%ile (↓ Low)
0 Median expression score Group median: 0 • 6.6%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

51.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.84
bar=donor   line=cohort median 		2.02 20.6%
FOXO3 Insulin/IGF-1 Signaling 10.03
bar=donor   line=cohort median 		9.99 55.0%
CETP Lipid Metabolism 5.02
bar=donor   line=cohort median 		5.05 46.4%
SIRT6 Sirtuin Family 8.33
bar=donor   line=cohort median 		8.34 48.6%
SIRT1 Sirtuin Family 8.80
bar=donor   line=cohort median 		8.72 66.1%
SIRT3 Sirtuin Family 7.13
bar=donor   line=cohort median 		7.49 3.8%
IGF1R Insulin/IGF-1 Signaling 10.34
bar=donor   line=cohort median 		10.21 66.5%
KLOTHO Anti-aging 2.61
bar=donor   line=cohort median 		2.51 65.4%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 13.8%
IL6 Inflammation 1.28
bar=donor   line=cohort median 		1.16 70.8%
TERT Telomere Maintenance 1.62
bar=donor   line=cohort median 		1.51 73.3%
IRS2 Insulin/IGF-1 Signaling 9.54
bar=donor   line=cohort median 		9.81 25.3%
TP53 Tumor Suppression 9.03
bar=donor   line=cohort median 		8.92 70.1%
SHC1 Signal Transduction 9.42
bar=donor   line=cohort median 		9.35 72.6%
ACE Signal Transduction 4.84
bar=donor   line=cohort median 		4.64 70.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.3 0
2 B2M 17.1 0
3 EEF1A1 16.9 0
4 ACTB 16.7 0
5 MT-CO1 16.3 0
6 HLA-B 16.1 0
7 HLA-C 16.0 0
8 HLA-E 15.8 0
9 MT-RNR1 15.7 0
10 S100A9 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.1
bar=donor   line=cohort median 		13.8 14.2 44.3%
2 S100A9 15.6
bar=donor   line=cohort median 		15.3 15.5 59.3%
3 IL1B 9.6
bar=donor   line=cohort median 		9.5 9.3 69.0%
4 CXCL8 10.7
bar=donor   line=cohort median 		10.6 11.4 36.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.1
bar=donor   line=cohort median 		6.0 6.1 54.3%
6 FCGR3B 15.6
bar=donor   line=cohort median 		14.6 14.7 98.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 15.0
bar=donor   line=cohort median 		14.3 14.3 94.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.5
bar=donor   line=cohort median 		10.2 10.4 72.2%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 38.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.8
bar=donor   line=cohort median 		11.0 10.9 99.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.1
bar=donor   line=cohort median 		11.7 11.7 76.9%
12 GNLY 12.2
bar=donor   line=cohort median 		12.0 12.1 53.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 24.2%
17 MT-CO2 15.1
bar=donor   line=cohort median 		15.2 15.3 16.7%
18 MT-ND1 14.7
bar=donor   line=cohort median 		15.0 15.2 3.0%
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