GSM8077462

Dataset: gse255685 • Sample: YZ353 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 55.4%ile (≈ Median)
22,378 Genes with score > 0 Group median: 22,375 • 50.0%ile (≈ Median)
0 Median expression score Group median: 0 • 34.6%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

53.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.70
bar=donor   line=cohort median 		2.02 98.4%
FOXO3 Insulin/IGF-1 Signaling 10.10
bar=donor   line=cohort median 		9.99 66.9%
CETP Lipid Metabolism 4.73
bar=donor   line=cohort median 		5.05 15.2%
SIRT6 Sirtuin Family 8.44
bar=donor   line=cohort median 		8.34 69.4%
SIRT1 Sirtuin Family 8.58
bar=donor   line=cohort median 		8.72 31.4%
SIRT3 Sirtuin Family 7.57
bar=donor   line=cohort median 		7.49 63.6%
IGF1R Insulin/IGF-1 Signaling 10.34
bar=donor   line=cohort median 		10.21 65.4%
KLOTHO Anti-aging 2.51
bar=donor   line=cohort median 		2.51 50.0%
APOC3 Lipid Metabolism -1.97
bar=donor   line=cohort median 		-2.11 99.1%
IL6 Inflammation 1.17
bar=donor   line=cohort median 		1.16 53.9%
TERT Telomere Maintenance 1.34
bar=donor   line=cohort median 		1.51 12.7%
IRS2 Insulin/IGF-1 Signaling 10.07
bar=donor   line=cohort median 		9.81 67.6%
TP53 Tumor Suppression 8.93
bar=donor   line=cohort median 		8.92 51.1%
SHC1 Signal Transduction 9.24
bar=donor   line=cohort median 		9.35 13.1%
ACE Signal Transduction 4.61
bar=donor   line=cohort median 		4.64 48.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.7 0
2 EEF1A1 17.0 0
3 B2M 16.9 0
4 MT-CO1 16.6 0
5 ACTB 16.6 0
6 MT-RNR1 16.3 0
7 HLA-C 16.3 0
8 FKBP8 16.2 0
9 FTL 16.0 0
10 UBA52 16.0 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.8
bar=donor   line=cohort median 		13.8 14.2 28.9%
2 S100A9 15.4
bar=donor   line=cohort median 		15.3 15.5 38.5%
3 IL1B 8.2
bar=donor   line=cohort median 		9.5 9.3 9.1%
4 CXCL8 9.9
bar=donor   line=cohort median 		10.6 11.4 25.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 7.1
bar=donor   line=cohort median 		6.0 6.1 88.7%
6 FCGR3B 14.2
bar=donor   line=cohort median 		14.6 14.7 14.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.2
bar=donor   line=cohort median 		14.3 14.3 38.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.7
bar=donor   line=cohort median 		10.2 10.4 83.7%
9 CD3E 12.3
bar=donor   line=cohort median 		11.9 12.0 88.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.5
bar=donor   line=cohort median 		11.0 10.9 14.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.7
bar=donor   line=cohort median 		11.7 11.7 53.9%
12 GNLY 12.3
bar=donor   line=cohort median 		12.0 12.1 62.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.6
bar=donor   line=cohort median 		16.4 16.4 87.3%
17 MT-CO2 15.6
bar=donor   line=cohort median 		15.2 15.3 84.1%
18 MT-ND1 15.5
bar=donor   line=cohort median 		15.0 15.2 80.5%
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