GSM8077463

Dataset: gse255685 • Sample: YZ359 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 18.1%ile (↓ Low)
22,344 Genes with score > 0 Group median: 22,378 • 10.6%ile (↓ Low)
0 Median expression score Group median: 0 • 5.9%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

53.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.98
bar=donor   line=cohort median 		2.02 44.6%
FOXO3 Insulin/IGF-1 Signaling 9.92
bar=donor   line=cohort median 		9.99 41.4%
CETP Lipid Metabolism 5.35
bar=donor   line=cohort median 		5.05 83.3%
SIRT6 Sirtuin Family 8.45
bar=donor   line=cohort median 		8.34 70.1%
SIRT1 Sirtuin Family 8.74
bar=donor   line=cohort median 		8.72 54.3%
SIRT3 Sirtuin Family 7.60
bar=donor   line=cohort median 		7.49 68.3%
IGF1R Insulin/IGF-1 Signaling 10.44
bar=donor   line=cohort median 		10.21 75.5%
KLOTHO Anti-aging 3.40
bar=donor   line=cohort median 		2.51 99.8%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 59.3%
IL6 Inflammation 1.19
bar=donor   line=cohort median 		1.16 57.2%
TERT Telomere Maintenance 1.29
bar=donor   line=cohort median 		1.51 4.5%
IRS2 Insulin/IGF-1 Signaling 9.65
bar=donor   line=cohort median 		9.81 33.2%
TP53 Tumor Suppression 9.12
bar=donor   line=cohort median 		8.92 82.6%
SHC1 Signal Transduction 9.25
bar=donor   line=cohort median 		9.35 18.8%
ACE Signal Transduction 4.22
bar=donor   line=cohort median 		4.64 9.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.7 0
2 B2M 16.9 0
3 EEF1A1 16.7 0
4 ACTB 16.7 0
5 MT-CO1 16.4 0
6 HLA-C 16.3 0
7 MT-RNR1 16.1 0
8 HLA-B 16.0 0
9 S100A9 15.9 0
10 MT-ND4 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.7
bar=donor   line=cohort median 		14.2 14.2 82.6%
2 S100A9 15.9
bar=donor   line=cohort median 		15.4 15.5 75.1%
3 IL1B 9.6
bar=donor   line=cohort median 		9.5 9.3 65.1%
4 CXCL8 9.1
bar=donor   line=cohort median 		10.3 11.4 12.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 8.1
bar=donor   line=cohort median 		6.1 6.1 97.7%
6 FCGR3B 14.8
bar=donor   line=cohort median 		14.7 14.7 60.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.8
bar=donor   line=cohort median 		14.4 14.3 84.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.3
bar=donor   line=cohort median 		10.3 10.4 47.1%
9 CD3E 11.8
bar=donor   line=cohort median 		11.9 12.0 22.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		10.9 10.9 52.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.7
bar=donor   line=cohort median 		11.5 11.7 51.1%
12 GNLY 12.7
bar=donor   line=cohort median 		12.0 12.1 82.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 40.0%
17 MT-CO2 15.3
bar=donor   line=cohort median 		15.3 15.3 40.0%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.2 15.2 41.0%
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