GSM8077464

Dataset: gse255685 • Sample: YZ362 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 52.9%ile (≈ Median)
22,395 Genes with score > 0 Group median: 22,378 • 71.3%ile (≈ Median)
0 Median expression score Group median: 0 • 68.3%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

49.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.79
bar=donor   line=cohort median 		2.02 12.0%
FOXO3 Insulin/IGF-1 Signaling 10.01
bar=donor   line=cohort median 		9.99 53.2%
CETP Lipid Metabolism 4.94
bar=donor   line=cohort median 		5.05 36.4%
SIRT6 Sirtuin Family 8.33
bar=donor   line=cohort median 		8.34 47.9%
SIRT1 Sirtuin Family 8.78
bar=donor   line=cohort median 		8.72 62.9%
SIRT3 Sirtuin Family 7.67
bar=donor   line=cohort median 		7.49 81.5%
IGF1R Insulin/IGF-1 Signaling 10.53
bar=donor   line=cohort median 		10.21 84.4%
KLOTHO Anti-aging 2.31
bar=donor   line=cohort median 		2.51 19.2%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 37.1%
IL6 Inflammation 1.24
bar=donor   line=cohort median 		1.16 65.8%
TERT Telomere Maintenance 1.52
bar=donor   line=cohort median 		1.51 51.4%
IRS2 Insulin/IGF-1 Signaling 9.88
bar=donor   line=cohort median 		9.81 56.1%
TP53 Tumor Suppression 8.83
bar=donor   line=cohort median 		8.92 41.8%
SHC1 Signal Transduction 9.30
bar=donor   line=cohort median 		9.35 29.9%
ACE Signal Transduction 4.81
bar=donor   line=cohort median 		4.64 65.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.7 0
2 B2M 16.9 0
3 EEF1A1 16.7 0
4 ACTB 16.4 0
5 MT-CO1 16.3 0
6 HLA-C 16.2 0
7 MT-RNR1 16.1 0
8 HLA-E 15.8 0
9 HLA-B 15.7 0
10 S100A9 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.7
bar=donor   line=cohort median 		14.2 14.2 81.5%
2 S100A9 15.7
bar=donor   line=cohort median 		15.4 15.5 64.7%
3 IL1B 10.6
bar=donor   line=cohort median 		9.5 9.3 99.5%
4 CXCL8 11.6
bar=donor   line=cohort median 		10.3 11.4 55.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.0
bar=donor   line=cohort median 		6.1 6.1 45.3%
6 FCGR3B 14.8
bar=donor   line=cohort median 		14.7 14.7 63.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.1
bar=donor   line=cohort median 		14.4 14.3 32.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.4
bar=donor   line=cohort median 		10.3 10.4 53.6%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 51.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.8
bar=donor   line=cohort median 		10.9 10.9 36.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.0
bar=donor   line=cohort median 		11.5 11.7 2.3%
12 GNLY 11.4
bar=donor   line=cohort median 		12.0 12.1 5.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 27.4%
17 MT-CO2 15.3
bar=donor   line=cohort median 		15.3 15.3 41.8%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.2 15.2 58.6%
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