GSM8077467

Dataset: gse255685 • Sample: YZ391 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 83.0%ile (↑ High)
22,367 Genes with score > 0 Group median: 22,378 • 34.8%ile (≈ Median)
0 Median expression score Group median: 0 • 30.3%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

49.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.40
bar=donor   line=cohort median 		2.02 87.6%
FOXO3 Insulin/IGF-1 Signaling 9.81
bar=donor   line=cohort median 		9.99 26.3%
CETP Lipid Metabolism 5.12
bar=donor   line=cohort median 		5.05 61.8%
SIRT6 Sirtuin Family 8.42
bar=donor   line=cohort median 		8.34 65.8%
SIRT1 Sirtuin Family 8.54
bar=donor   line=cohort median 		8.72 23.8%
SIRT3 Sirtuin Family 7.60
bar=donor   line=cohort median 		7.49 67.6%
IGF1R Insulin/IGF-1 Signaling 9.74
bar=donor   line=cohort median 		10.21 13.1%
KLOTHO Anti-aging 2.21
bar=donor   line=cohort median 		2.51 11.3%
APOC3 Lipid Metabolism -2.10
bar=donor   line=cohort median 		-2.11 93.7%
IL6 Inflammation 1.06
bar=donor   line=cohort median 		1.16 21.7%
TERT Telomere Maintenance 1.95
bar=donor   line=cohort median 		1.51 98.0%
IRS2 Insulin/IGF-1 Signaling 9.54
bar=donor   line=cohort median 		9.81 24.9%
TP53 Tumor Suppression 8.72
bar=donor   line=cohort median 		8.92 29.2%
SHC1 Signal Transduction 9.27
bar=donor   line=cohort median 		9.35 24.2%
ACE Signal Transduction 5.15
bar=donor   line=cohort median 		4.64 93.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.7 0
2 B2M 17.4 0
3 EEF1A1 17.0 0
4 ACTB 16.5 0
5 MT-CO1 16.5 0
6 HLA-C 16.3 0
7 MT-RNR1 16.2 0
8 UBA52 16.1 0
9 FTL 16.1 0
10 S100A9 16.1 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 15.1
bar=donor   line=cohort median 		14.2 14.2 94.1%
2 S100A9 16.1
bar=donor   line=cohort median 		15.4 15.5 83.0%
3 IL1B 9.3
bar=donor   line=cohort median 		9.5 9.3 46.4%
4 CXCL8 10.9
bar=donor   line=cohort median 		10.3 11.4 41.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.3
bar=donor   line=cohort median 		6.1 6.1 63.6%
6 FCGR3B 14.8
bar=donor   line=cohort median 		14.7 14.7 61.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.2
bar=donor   line=cohort median 		14.4 14.3 41.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.7
bar=donor   line=cohort median 		10.3 10.4 87.3%
9 CD3E 12.1
bar=donor   line=cohort median 		11.9 12.0 66.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		10.9 10.9 42.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.4
bar=donor   line=cohort median 		11.5 11.7 24.2%
12 GNLY 11.3
bar=donor   line=cohort median 		12.0 12.1 3.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 59.3%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.3 15.3 56.8%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.2 15.2 65.8%
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