GSM8077469

Dataset: gse255685 • Sample: YZ406 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 84.8%ile (↑ High)
22,375 Genes with score > 0 Group median: 22,378 • 45.0%ile (≈ Median)
0 Median expression score Group median: 0 • 65.8%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

53.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.89
bar=donor   line=cohort median 		2.02 30.3%
FOXO3 Insulin/IGF-1 Signaling 10.15
bar=donor   line=cohort median 		9.99 76.5%
CETP Lipid Metabolism 5.59
bar=donor   line=cohort median 		5.05 93.7%
SIRT6 Sirtuin Family 8.31
bar=donor   line=cohort median 		8.34 42.8%
SIRT1 Sirtuin Family 8.77
bar=donor   line=cohort median 		8.72 60.0%
SIRT3 Sirtuin Family 7.63
bar=donor   line=cohort median 		7.49 75.1%
IGF1R Insulin/IGF-1 Signaling 10.52
bar=donor   line=cohort median 		10.21 84.1%
KLOTHO Anti-aging 2.26
bar=donor   line=cohort median 		2.51 13.4%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 55.0%
IL6 Inflammation 1.09
bar=donor   line=cohort median 		1.16 33.2%
TERT Telomere Maintenance 1.54
bar=donor   line=cohort median 		1.51 56.8%
IRS2 Insulin/IGF-1 Signaling 9.62
bar=donor   line=cohort median 		9.81 30.7%
TP53 Tumor Suppression 8.80
bar=donor   line=cohort median 		8.92 39.6%
SHC1 Signal Transduction 9.30
bar=donor   line=cohort median 		9.35 31.0%
ACE Signal Transduction 4.98
bar=donor   line=cohort median 		4.64 81.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.8 0
2 B2M 17.1 0
3 EEF1A1 16.4 0
4 ACTB 16.4 0
5 HLA-B 16.3 0
6 MT-CO1 16.2 0
7 MT-RNR1 16.2 0
8 FCGR3B 15.9 0
9 HLA-C 15.9 0
10 HLA-E 15.9 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.6
bar=donor   line=cohort median 		14.2 14.2 78.0%
2 S100A9 15.7
bar=donor   line=cohort median 		15.4 15.5 64.0%
3 IL1B 9.9
bar=donor   line=cohort median 		9.5 9.3 80.8%
4 CXCL8 10.4
bar=donor   line=cohort median 		10.3 11.4 32.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.1
bar=donor   line=cohort median 		6.1 6.1 55.4%
6 FCGR3B 15.9
bar=donor   line=cohort median 		14.7 14.7 99.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.1
bar=donor   line=cohort median 		14.4 14.3 33.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.0
bar=donor   line=cohort median 		10.3 10.4 13.4%
9 CD3E 11.8
bar=donor   line=cohort median 		11.9 12.0 15.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.1
bar=donor   line=cohort median 		10.9 10.9 75.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.5
bar=donor   line=cohort median 		11.5 11.7 35.7%
12 GNLY 11.6
bar=donor   line=cohort median 		12.0 12.1 12.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.2
bar=donor   line=cohort median 		16.4 16.4 11.6%
17 MT-CO2 15.2
bar=donor   line=cohort median 		15.3 15.3 34.9%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.2 15.2 40.7%
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