GSM8077470

Dataset: gse255685 • Sample: YZ407 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 29.2%ile (≈ Median)
22,328 Genes with score > 0 Group median: 22,378 • 3.9%ile (↓ Low)
0 Median expression score Group median: 0 • 3.0%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

58.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.04
bar=donor   line=cohort median 		2.02 54.3%
FOXO3 Insulin/IGF-1 Signaling 9.62
bar=donor   line=cohort median 		9.99 7.4%
CETP Lipid Metabolism 5.51
bar=donor   line=cohort median 		5.05 90.9%
SIRT6 Sirtuin Family 8.34
bar=donor   line=cohort median 		8.34 51.1%
SIRT1 Sirtuin Family 8.66
bar=donor   line=cohort median 		8.72 43.6%
SIRT3 Sirtuin Family 7.38
bar=donor   line=cohort median 		7.49 31.7%
IGF1R Insulin/IGF-1 Signaling 9.89
bar=donor   line=cohort median 		10.21 23.8%
KLOTHO Anti-aging 2.71
bar=donor   line=cohort median 		2.51 77.2%
APOC3 Lipid Metabolism -2.10
bar=donor   line=cohort median 		-2.11 81.5%
IL6 Inflammation 1.70
bar=donor   line=cohort median 		1.16 97.3%
TERT Telomere Maintenance 1.84
bar=donor   line=cohort median 		1.51 93.7%
IRS2 Insulin/IGF-1 Signaling 8.91
bar=donor   line=cohort median 		9.81 0.5%
TP53 Tumor Suppression 9.12
bar=donor   line=cohort median 		8.92 83.0%
SHC1 Signal Transduction 9.32
bar=donor   line=cohort median 		9.35 39.6%
ACE Signal Transduction 5.21
bar=donor   line=cohort median 		4.64 94.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.8 0
2 B2M 17.4 0
3 ACTB 16.8 0
4 EEF1A1 16.7 0
5 HLA-C 16.6 0
6 HLA-E 16.4 0
7 MT-CO1 16.4 0
8 S100A9 16.3 0
9 MT-RNR1 16.3 0
10 HLA-B 16.1 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 15.3
bar=donor   line=cohort median 		14.2 14.2 97.3%
2 S100A9 16.3
bar=donor   line=cohort median 		15.4 15.5 92.3%
3 IL1B 10.4
bar=donor   line=cohort median 		9.5 9.3 96.6%
4 CXCL8 9.7
bar=donor   line=cohort median 		10.3 11.4 22.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.0
bar=donor   line=cohort median 		6.1 6.1 44.6%
6 FCGR3B 15.2
bar=donor   line=cohort median 		14.7 14.7 87.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.2
bar=donor   line=cohort median 		14.4 14.3 42.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.3
bar=donor   line=cohort median 		10.3 10.4 48.2%
9 CD3E 11.8
bar=donor   line=cohort median 		11.9 12.0 26.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		10.9 10.9 46.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.7
bar=donor   line=cohort median 		11.5 11.7 51.4%
12 GNLY 12.5
bar=donor   line=cohort median 		12.0 12.1 74.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 38.2%
17 MT-CO2 15.5
bar=donor   line=cohort median 		15.3 15.3 68.6%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.2 15.2 60.0%
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