GSM8077471

Dataset: gse255685 • Sample: YZ408 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 54.7%ile (≈ Median)
22,404 Genes with score > 0 Group median: 22,378 • 76.5%ile (↑ High)
0 Median expression score Group median: 0 • 73.7%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

41.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.84
bar=donor   line=cohort median 		2.02 19.5%
FOXO3 Insulin/IGF-1 Signaling 10.29
bar=donor   line=cohort median 		9.99 89.1%
CETP Lipid Metabolism 4.83
bar=donor   line=cohort median 		5.05 24.6%
SIRT6 Sirtuin Family 8.11
bar=donor   line=cohort median 		8.34 6.3%
SIRT1 Sirtuin Family 8.57
bar=donor   line=cohort median 		8.72 28.5%
SIRT3 Sirtuin Family 7.51
bar=donor   line=cohort median 		7.49 54.3%
IGF1R Insulin/IGF-1 Signaling 10.39
bar=donor   line=cohort median 		10.21 70.8%
KLOTHO Anti-aging 2.47
bar=donor   line=cohort median 		2.51 47.1%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 76.9%
IL6 Inflammation 1.01
bar=donor   line=cohort median 		1.16 14.9%
TERT Telomere Maintenance 1.40
bar=donor   line=cohort median 		1.51 25.6%
IRS2 Insulin/IGF-1 Signaling 10.10
bar=donor   line=cohort median 		9.81 69.0%
TP53 Tumor Suppression 8.59
bar=donor   line=cohort median 		8.92 16.0%
SHC1 Signal Transduction 9.15
bar=donor   line=cohort median 		9.35 5.2%
ACE Signal Transduction 4.84
bar=donor   line=cohort median 		4.64 71.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.4 0
2 B2M 17.0 0
3 EEF1A1 16.9 0
4 MT-CO1 16.5 0
5 ACTB 16.4 0
6 HLA-C 16.1 0
7 MT-RNR1 15.8 0
8 MT-ND4 15.8 0
9 FTL 15.8 0
10 HLA-B 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.4
bar=donor   line=cohort median 		14.2 14.2 65.4%
2 S100A9 15.5
bar=donor   line=cohort median 		15.4 15.5 50.7%
3 IL1B 8.8
bar=donor   line=cohort median 		9.5 9.3 25.6%
4 CXCL8 12.3
bar=donor   line=cohort median 		10.3 11.4 80.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.0
bar=donor   line=cohort median 		6.1 6.1 42.8%
6 FCGR3B 14.3
bar=donor   line=cohort median 		14.7 14.7 22.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 13.8
bar=donor   line=cohort median 		14.4 14.3 12.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.5
bar=donor   line=cohort median 		10.3 10.4 69.7%
9 CD3E 12.1
bar=donor   line=cohort median 		11.9 12.0 74.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.0
bar=donor   line=cohort median 		10.9 10.9 61.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.5
bar=donor   line=cohort median 		11.5 11.7 33.5%
12 GNLY 11.9
bar=donor   line=cohort median 		12.0 12.1 30.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 67.2%
17 MT-CO2 15.5
bar=donor   line=cohort median 		15.3 15.3 71.9%
18 MT-ND1 15.4
bar=donor   line=cohort median 		15.2 15.2 75.1%
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