GSM8077474

Dataset: gse255685 • Sample: YZ425 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 13.1%ile (↓ Low)
22,329 Genes with score > 0 Group median: 22,378 • 4.8%ile (↓ Low)
0 Median expression score Group median: 0 • 7.7%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

50.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.75
bar=donor   line=cohort median 		2.02 7.7%
FOXO3 Insulin/IGF-1 Signaling 9.84
bar=donor   line=cohort median 		9.99 28.1%
CETP Lipid Metabolism 5.87
bar=donor   line=cohort median 		5.05 98.0%
SIRT6 Sirtuin Family 8.44
bar=donor   line=cohort median 		8.34 69.0%
SIRT1 Sirtuin Family 8.78
bar=donor   line=cohort median 		8.72 63.3%
SIRT3 Sirtuin Family 7.46
bar=donor   line=cohort median 		7.49 42.1%
IGF1R Insulin/IGF-1 Signaling 9.69
bar=donor   line=cohort median 		10.21 9.9%
KLOTHO Anti-aging 2.86
bar=donor   line=cohort median 		2.51 88.7%
APOC3 Lipid Metabolism -2.10
bar=donor   line=cohort median 		-2.11 86.2%
IL6 Inflammation 1.02
bar=donor   line=cohort median 		1.16 17.0%
TERT Telomere Maintenance 1.43
bar=donor   line=cohort median 		1.51 29.2%
IRS2 Insulin/IGF-1 Signaling 9.00
bar=donor   line=cohort median 		9.81 1.3%
TP53 Tumor Suppression 9.25
bar=donor   line=cohort median 		8.92 94.4%
SHC1 Signal Transduction 9.40
bar=donor   line=cohort median 		9.35 65.1%
ACE Signal Transduction 4.72
bar=donor   line=cohort median 		4.64 59.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.8 0
2 B2M 17.5 0
3 EEF1A1 16.9 0
4 ACTB 16.9 0
5 HLA-C 16.6 0
6 MT-CO1 16.4 0
7 HLA-B 16.3 0
8 S100A9 16.3 0
9 MT-RNR1 16.2 0
10 HLA-E 16.0 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 15.2
bar=donor   line=cohort median 		14.2 14.2 96.6%
2 S100A9 16.3
bar=donor   line=cohort median 		15.4 15.5 92.7%
3 IL1B 10.6
bar=donor   line=cohort median 		9.5 9.3 99.1%
4 CXCL8 9.1
bar=donor   line=cohort median 		10.3 11.4 12.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.3
bar=donor   line=cohort median 		6.1 6.1 65.1%
6 FCGR3B 14.5
bar=donor   line=cohort median 		14.7 14.7 37.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.9
bar=donor   line=cohort median 		14.4 14.3 88.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.2
bar=donor   line=cohort median 		10.3 10.4 29.2%
9 CD3E 11.8
bar=donor   line=cohort median 		11.9 12.0 16.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.6
bar=donor   line=cohort median 		10.9 10.9 20.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.6
bar=donor   line=cohort median 		11.5 11.7 40.7%
12 GNLY 12.1
bar=donor   line=cohort median 		12.0 12.1 46.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 34.9%
17 MT-CO2 15.3
bar=donor   line=cohort median 		15.3 15.3 49.3%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.2 15.2 58.2%
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