GSM8077478

Dataset: gse255685 • Sample: YZ435 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 54.3%ile (≈ Median)
22,348 Genes with score > 0 Group median: 22,375 • 12.9%ile (↓ Low)
0 Median expression score Group median: 0 • 25.6%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

54.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.79
bar=donor   line=cohort median 		2.02 13.1%
FOXO3 Insulin/IGF-1 Signaling 10.05
bar=donor   line=cohort median 		9.99 58.6%
CETP Lipid Metabolism 5.67
bar=donor   line=cohort median 		5.05 95.9%
SIRT6 Sirtuin Family 8.30
bar=donor   line=cohort median 		8.34 39.6%
SIRT1 Sirtuin Family 8.75
bar=donor   line=cohort median 		8.72 55.4%
SIRT3 Sirtuin Family 7.30
bar=donor   line=cohort median 		7.49 16.0%
IGF1R Insulin/IGF-1 Signaling 10.58
bar=donor   line=cohort median 		10.21 88.4%
KLOTHO Anti-aging 2.95
bar=donor   line=cohort median 		2.51 94.4%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 40.7%
IL6 Inflammation 1.17
bar=donor   line=cohort median 		1.16 52.9%
TERT Telomere Maintenance 1.45
bar=donor   line=cohort median 		1.51 36.7%
IRS2 Insulin/IGF-1 Signaling 9.15
bar=donor   line=cohort median 		9.81 3.8%
TP53 Tumor Suppression 9.10
bar=donor   line=cohort median 		8.92 78.3%
SHC1 Signal Transduction 9.54
bar=donor   line=cohort median 		9.35 90.9%
ACE Signal Transduction 4.67
bar=donor   line=cohort median 		4.64 51.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.2 0
2 B2M 17.1 0
3 ACTB 16.9 0
4 HLA-C 16.6 0
5 EEF1A1 16.6 0
6 S100A9 16.4 0
7 MT-CO1 16.4 0
8 HLA-E 16.0 0
9 CSF3R 16.0 0
10 HLA-B 15.9 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.9
bar=donor   line=cohort median 		13.8 14.2 90.5%
2 S100A9 16.4
bar=donor   line=cohort median 		15.3 15.5 94.8%
3 IL1B 10.7
bar=donor   line=cohort median 		9.5 9.3 99.8%
4 CXCL8 9.1
bar=donor   line=cohort median 		10.6 11.4 13.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.9
bar=donor   line=cohort median 		6.0 6.1 38.2%
6 FCGR3B 15.5
bar=donor   line=cohort median 		14.6 14.7 97.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.8
bar=donor   line=cohort median 		14.3 14.3 84.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.0
bar=donor   line=cohort median 		10.2 10.4 10.6%
9 CD3E 11.6
bar=donor   line=cohort median 		11.9 12.0 4.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.5
bar=donor   line=cohort median 		11.0 10.9 11.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.5
bar=donor   line=cohort median 		11.7 11.7 38.9%
12 GNLY 11.8
bar=donor   line=cohort median 		12.0 12.1 27.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 39.2%
17 MT-CO2 15.0
bar=donor   line=cohort median 		15.2 15.3 14.5%
18 MT-ND1 15.1
bar=donor   line=cohort median 		15.0 15.2 26.0%
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