GSM8077480

Dataset: gse255685 • Sample: YZ450 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 85.8%ile (↑ High)
22,403 Genes with score > 0 Group median: 22,378 • 75.6%ile (↑ High)
0 Median expression score Group median: 0 • 85.1%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

50.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.93
bar=donor   line=cohort median 		2.02 36.0%
FOXO3 Insulin/IGF-1 Signaling 10.17
bar=donor   line=cohort median 		9.99 78.3%
CETP Lipid Metabolism 4.84
bar=donor   line=cohort median 		5.05 26.0%
SIRT6 Sirtuin Family 8.03
bar=donor   line=cohort median 		8.34 2.3%
SIRT1 Sirtuin Family 8.71
bar=donor   line=cohort median 		8.72 49.3%
SIRT3 Sirtuin Family 7.78
bar=donor   line=cohort median 		7.49 94.1%
IGF1R Insulin/IGF-1 Signaling 10.25
bar=donor   line=cohort median 		10.21 55.0%
KLOTHO Anti-aging 2.53
bar=donor   line=cohort median 		2.51 53.9%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 71.5%
IL6 Inflammation 1.11
bar=donor   line=cohort median 		1.16 36.4%
TERT Telomere Maintenance 1.58
bar=donor   line=cohort median 		1.51 64.0%
IRS2 Insulin/IGF-1 Signaling 9.98
bar=donor   line=cohort median 		9.81 62.9%
TP53 Tumor Suppression 8.59
bar=donor   line=cohort median 		8.92 15.2%
SHC1 Signal Transduction 9.22
bar=donor   line=cohort median 		9.35 9.9%
ACE Signal Transduction 5.33
bar=donor   line=cohort median 		4.64 97.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.4 0
2 EEF1A1 16.9 0
3 B2M 16.8 0
4 MT-CO1 16.5 0
5 ACTB 16.2 0
6 MT-RNR1 15.8 0
7 MT-ND4 15.8 0
8 HLA-C 15.6 0
9 FTL 15.6 0
10 HLA-E 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.2
bar=donor   line=cohort median 		14.2 14.2 49.3%
2 S100A9 15.2
bar=donor   line=cohort median 		15.4 15.5 25.3%
3 IL1B 8.1
bar=donor   line=cohort median 		9.5 9.3 6.6%
4 CXCL8 10.4
bar=donor   line=cohort median 		10.3 11.4 32.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.8
bar=donor   line=cohort median 		6.1 6.1 84.4%
6 FCGR3B 13.4
bar=donor   line=cohort median 		14.7 14.7 0.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.4
bar=donor   line=cohort median 		14.4 14.3 55.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.4
bar=donor   line=cohort median 		10.3 10.4 59.0%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 54.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.1
bar=donor   line=cohort median 		10.9 10.9 75.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.1
bar=donor   line=cohort median 		11.5 11.7 9.1%
12 GNLY 11.4
bar=donor   line=cohort median 		12.0 12.1 5.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 71.9%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.3 15.3 67.9%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.2 15.2 66.5%
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