GSM8077481

Dataset: gse255685 • Sample: YZ452 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 11.6%ile (↓ Low)
22,352 Genes with score > 0 Group median: 22,378 • 16.5%ile (↓ Low)
0 Median expression score Group median: 0 • 17.4%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

52.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.89
bar=donor   line=cohort median 		2.02 30.7%
FOXO3 Insulin/IGF-1 Signaling 10.06
bar=donor   line=cohort median 		9.99 60.0%
CETP Lipid Metabolism 5.08
bar=donor   line=cohort median 		5.05 56.5%
SIRT6 Sirtuin Family 8.23
bar=donor   line=cohort median 		8.34 24.2%
SIRT1 Sirtuin Family 9.01
bar=donor   line=cohort median 		8.72 95.2%
SIRT3 Sirtuin Family 7.35
bar=donor   line=cohort median 		7.49 26.3%
IGF1R Insulin/IGF-1 Signaling 10.24
bar=donor   line=cohort median 		10.21 53.2%
KLOTHO Anti-aging 2.41
bar=donor   line=cohort median 		2.51 35.7%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 55.4%
IL6 Inflammation 1.18
bar=donor   line=cohort median 		1.16 56.1%
TERT Telomere Maintenance 1.62
bar=donor   line=cohort median 		1.51 74.4%
IRS2 Insulin/IGF-1 Signaling 9.85
bar=donor   line=cohort median 		9.81 52.5%
TP53 Tumor Suppression 9.05
bar=donor   line=cohort median 		8.92 72.9%
SHC1 Signal Transduction 9.40
bar=donor   line=cohort median 		9.35 66.5%
ACE Signal Transduction 4.36
bar=donor   line=cohort median 		4.64 21.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.6 0
2 B2M 17.1 0
3 EEF1A1 16.7 0
4 ACTB 16.6 0
5 MT-CO1 16.2 0
6 MT-RNR1 16.1 0
7 HLA-C 15.9 0
8 S100A9 15.8 0
9 TXNIP 15.8 0
10 FTL 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.6
bar=donor   line=cohort median 		14.2 14.2 78.3%
2 S100A9 15.8
bar=donor   line=cohort median 		15.4 15.5 69.7%
3 IL1B 10.1
bar=donor   line=cohort median 		9.5 9.3 90.5%
4 CXCL8 9.5
bar=donor   line=cohort median 		10.3 11.4 18.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.2
bar=donor   line=cohort median 		6.1 6.1 62.5%
6 FCGR3B 15.1
bar=donor   line=cohort median 		14.7 14.7 78.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 15.1
bar=donor   line=cohort median 		14.4 14.3 95.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.1
bar=donor   line=cohort median 		10.3 10.4 23.5%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 31.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		10.9 10.9 54.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.0
bar=donor   line=cohort median 		11.5 11.7 67.6%
12 GNLY 12.2
bar=donor   line=cohort median 		12.0 12.1 58.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.2
bar=donor   line=cohort median 		16.4 16.4 7.3%
17 MT-CO2 15.0
bar=donor   line=cohort median 		15.3 15.3 10.6%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.2 15.2 49.3%
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