GSM8077482

Dataset: gse255685 • Sample: YZ454 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 49.3%ile (≈ Median)
22,409 Genes with score > 0 Group median: 22,378 • 82.8%ile (↑ High)
0 Median expression score Group median: 0 • 77.6%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

58.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.80
bar=donor   line=cohort median 		2.02 14.5%
FOXO3 Insulin/IGF-1 Signaling 10.35
bar=donor   line=cohort median 		9.99 92.7%
CETP Lipid Metabolism 4.88
bar=donor   line=cohort median 		5.05 31.4%
SIRT6 Sirtuin Family 8.28
bar=donor   line=cohort median 		8.34 34.2%
SIRT1 Sirtuin Family 8.69
bar=donor   line=cohort median 		8.72 47.1%
SIRT3 Sirtuin Family 7.45
bar=donor   line=cohort median 		7.49 40.7%
IGF1R Insulin/IGF-1 Signaling 10.50
bar=donor   line=cohort median 		10.21 82.3%
KLOTHO Anti-aging 2.80
bar=donor   line=cohort median 		2.51 86.2%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 46.8%
IL6 Inflammation 1.17
bar=donor   line=cohort median 		1.16 54.3%
TERT Telomere Maintenance 1.67
bar=donor   line=cohort median 		1.51 80.8%
IRS2 Insulin/IGF-1 Signaling 10.74
bar=donor   line=cohort median 		9.81 91.2%
TP53 Tumor Suppression 8.56
bar=donor   line=cohort median 		8.92 14.2%
SHC1 Signal Transduction 9.41
bar=donor   line=cohort median 		9.35 69.4%
ACE Signal Transduction 5.15
bar=donor   line=cohort median 		4.64 92.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.2 0
2 EEF1A1 17.0 0
3 B2M 17.0 0
4 ACTB 16.6 0
5 MT-CO1 16.3 0
6 HLA-C 16.2 0
7 S100A9 16.0 0
8 HLA-B 15.9 0
9 HLA-E 15.8 0
10 FTL 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.8
bar=donor   line=cohort median 		14.2 14.2 87.6%
2 S100A9 16.0
bar=donor   line=cohort median 		15.4 15.5 80.8%
3 IL1B 8.7
bar=donor   line=cohort median 		9.5 9.3 23.1%
4 CXCL8 11.9
bar=donor   line=cohort median 		10.3 11.4 64.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.7
bar=donor   line=cohort median 		6.1 6.1 20.3%
6 FCGR3B 15.2
bar=donor   line=cohort median 		14.7 14.7 82.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 15.0
bar=donor   line=cohort median 		14.4 14.3 93.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.2
bar=donor   line=cohort median 		10.3 10.4 36.7%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 55.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.6
bar=donor   line=cohort median 		10.9 10.9 21.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.0
bar=donor   line=cohort median 		11.5 11.7 5.2%
12 GNLY 12.2
bar=donor   line=cohort median 		12.0 12.1 56.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 14.5%
17 MT-CO2 15.1
bar=donor   line=cohort median 		15.3 15.3 28.9%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.2 15.2 46.1%
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