GSM8077486

Dataset: gse255685 • Sample: YZ473 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 80.1%ile (↑ High)
22,444 Genes with score > 0 Group median: 22,378 • 96.8%ile (↑ High)
0 Median expression score Group median: 0 • 97.0%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

38.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.95
bar=donor   line=cohort median 		2.02 40.3%
FOXO3 Insulin/IGF-1 Signaling 9.87
bar=donor   line=cohort median 		9.99 32.1%
CETP Lipid Metabolism 4.89
bar=donor   line=cohort median 		5.05 33.2%
SIRT6 Sirtuin Family 8.09
bar=donor   line=cohort median 		8.34 4.5%
SIRT1 Sirtuin Family 8.79
bar=donor   line=cohort median 		8.72 64.3%
SIRT3 Sirtuin Family 7.44
bar=donor   line=cohort median 		7.49 39.3%
IGF1R Insulin/IGF-1 Signaling 9.96
bar=donor   line=cohort median 		10.21 27.4%
KLOTHO Anti-aging 2.37
bar=donor   line=cohort median 		2.51 29.2%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 8.1%
IL6 Inflammation 1.05
bar=donor   line=cohort median 		1.16 19.2%
TERT Telomere Maintenance 1.40
bar=donor   line=cohort median 		1.51 25.3%
IRS2 Insulin/IGF-1 Signaling 9.75
bar=donor   line=cohort median 		9.81 43.6%
TP53 Tumor Suppression 8.94
bar=donor   line=cohort median 		8.92 53.2%
SHC1 Signal Transduction 9.38
bar=donor   line=cohort median 		9.35 60.0%
ACE Signal Transduction 5.28
bar=donor   line=cohort median 		4.64 96.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.6 0
2 EEF1A1 16.8 0
3 B2M 16.7 0
4 MT-CO1 16.4 0
5 ACTB 16.1 0
6 MT-RNR1 15.8 0
7 MT-ND4 15.6 0
8 HLA-C 15.5 0
9 HLA-B 15.4 0
10 HLA-E 15.4 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.7
bar=donor   line=cohort median 		14.2 14.2 21.7%
2 S100A9 14.8
bar=donor   line=cohort median 		15.4 15.5 7.7%
3 IL1B 9.0
bar=donor   line=cohort median 		9.5 9.3 34.9%
4 CXCL8 11.9
bar=donor   line=cohort median 		10.3 11.4 63.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.8
bar=donor   line=cohort median 		6.1 6.1 24.2%
6 FCGR3B 13.9
bar=donor   line=cohort median 		14.7 14.7 8.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.5
bar=donor   line=cohort median 		14.4 14.3 64.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.3
bar=donor   line=cohort median 		10.3 10.4 42.8%
9 CD3E 11.8
bar=donor   line=cohort median 		11.9 12.0 21.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.1
bar=donor   line=cohort median 		10.9 10.9 76.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.1
bar=donor   line=cohort median 		11.5 11.7 8.1%
12 GNLY 11.6
bar=donor   line=cohort median 		12.0 12.1 13.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 40.3%
17 MT-CO2 15.3
bar=donor   line=cohort median 		15.3 15.3 44.6%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.2 15.2 62.2%
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