GSM8077487

Dataset: gse255685 • Sample: YZ475 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 91.9%ile (↑ High)
22,423 Genes with score > 0 Group median: 22,378 • 90.3%ile (↑ High)
0 Median expression score Group median: 0 • 80.8%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

59.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.37
bar=donor   line=cohort median 		2.02 86.6%
FOXO3 Insulin/IGF-1 Signaling 10.19
bar=donor   line=cohort median 		9.99 81.9%
CETP Lipid Metabolism 5.19
bar=donor   line=cohort median 		5.05 70.1%
SIRT6 Sirtuin Family 8.32
bar=donor   line=cohort median 		8.34 43.2%
SIRT1 Sirtuin Family 8.59
bar=donor   line=cohort median 		8.72 32.8%
SIRT3 Sirtuin Family 7.47
bar=donor   line=cohort median 		7.49 47.1%
IGF1R Insulin/IGF-1 Signaling 9.91
bar=donor   line=cohort median 		10.21 24.9%
KLOTHO Anti-aging 2.99
bar=donor   line=cohort median 		2.51 95.9%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 21.0%
IL6 Inflammation 1.57
bar=donor   line=cohort median 		1.16 94.4%
TERT Telomere Maintenance 1.56
bar=donor   line=cohort median 		1.51 61.5%
IRS2 Insulin/IGF-1 Signaling 10.02
bar=donor   line=cohort median 		9.81 65.8%
TP53 Tumor Suppression 8.63
bar=donor   line=cohort median 		8.92 18.1%
SHC1 Signal Transduction 9.50
bar=donor   line=cohort median 		9.35 86.2%
ACE Signal Transduction 4.70
bar=donor   line=cohort median 		4.64 56.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.4 0
2 B2M 17.2 0
3 ACTB 16.7 0
4 EEF1A1 16.5 0
5 HLA-C 16.4 0
6 MT-CO1 16.3 0
7 S100A9 16.2 0
8 HLA-E 16.0 0
9 HLA-B 15.9 0
10 TMSB4X 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 15.1
bar=donor   line=cohort median 		14.2 14.2 93.4%
2 S100A9 16.2
bar=donor   line=cohort median 		15.4 15.5 88.7%
3 IL1B 9.7
bar=donor   line=cohort median 		9.5 9.3 72.2%
4 CXCL8 11.6
bar=donor   line=cohort median 		10.3 11.4 57.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.9
bar=donor   line=cohort median 		6.1 6.1 37.1%
6 FCGR3B 15.5
bar=donor   line=cohort median 		14.7 14.7 97.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 15.1
bar=donor   line=cohort median 		14.4 14.3 96.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.9
bar=donor   line=cohort median 		10.3 10.4 8.4%
9 CD3E 11.6
bar=donor   line=cohort median 		11.9 12.0 2.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.0
bar=donor   line=cohort median 		10.9 10.9 1.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.8
bar=donor   line=cohort median 		11.5 11.7 58.6%
12 GNLY 12.1
bar=donor   line=cohort median 		12.0 12.1 46.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 17.7%
17 MT-CO2 15.1
bar=donor   line=cohort median 		15.3 15.3 15.9%
18 MT-ND1 15.1
bar=donor   line=cohort median 		15.2 15.2 37.8%
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