GSM8077489

Dataset: gse255685 • Sample: YZ481 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 96.6%ile (↑ High)
22,461 Genes with score > 0 Group median: 22,378 • 98.7%ile (↑ High)
0 Median expression score Group median: 0 • 97.3%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

48.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.41
bar=donor   line=cohort median 		2.02 88.7%
FOXO3 Insulin/IGF-1 Signaling 10.17
bar=donor   line=cohort median 		9.99 78.7%
CETP Lipid Metabolism 4.77
bar=donor   line=cohort median 		5.05 18.1%
SIRT6 Sirtuin Family 8.14
bar=donor   line=cohort median 		8.34 9.1%
SIRT1 Sirtuin Family 8.60
bar=donor   line=cohort median 		8.72 35.7%
SIRT3 Sirtuin Family 7.72
bar=donor   line=cohort median 		7.49 86.9%
IGF1R Insulin/IGF-1 Signaling 10.21
bar=donor   line=cohort median 		10.21 49.6%
KLOTHO Anti-aging 2.41
bar=donor   line=cohort median 		2.51 34.6%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 4.5%
IL6 Inflammation 1.24
bar=donor   line=cohort median 		1.16 66.5%
TERT Telomere Maintenance 1.95
bar=donor   line=cohort median 		1.51 97.7%
IRS2 Insulin/IGF-1 Signaling 10.67
bar=donor   line=cohort median 		9.81 89.8%
TP53 Tumor Suppression 8.58
bar=donor   line=cohort median 		8.92 14.9%
SHC1 Signal Transduction 9.17
bar=donor   line=cohort median 		9.35 7.0%
ACE Signal Transduction 4.64
bar=donor   line=cohort median 		4.64 50.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.2 0
2 EEF1A1 16.9 0
3 B2M 16.7 0
4 MT-CO1 16.2 0
5 ACTB 15.9 0
6 TXNIP 15.9 0
7 MT-RNR1 15.7 0
8 HLA-C 15.5 0
9 MT-ND4 15.5 0
10 HLA-E 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.5
bar=donor   line=cohort median 		14.2 14.2 15.6%
2 S100A9 14.8
bar=donor   line=cohort median 		15.4 15.5 5.9%
3 IL1B 7.3
bar=donor   line=cohort median 		9.5 9.3 0.2%
4 CXCL8 10.8
bar=donor   line=cohort median 		10.3 11.4 39.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.5
bar=donor   line=cohort median 		6.1 6.1 72.9%
6 FCGR3B 14.0
bar=donor   line=cohort median 		14.7 14.7 9.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.1
bar=donor   line=cohort median 		14.4 14.3 29.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.3
bar=donor   line=cohort median 		10.3 10.4 48.6%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 48.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.3
bar=donor   line=cohort median 		10.9 10.9 87.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 10.9
bar=donor   line=cohort median 		11.5 11.7 0.9%
12 GNLY 11.6
bar=donor   line=cohort median 		12.0 12.1 13.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.2
bar=donor   line=cohort median 		16.4 16.4 12.0%
17 MT-CO2 15.1
bar=donor   line=cohort median 		15.3 15.3 16.3%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.2 15.2 40.3%
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