GSM8077492

Dataset: gse255685 • Sample: YZ487 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 22.0%ile (↓ Low)
22,377 Genes with score > 0 Group median: 22,375 • 48.2%ile (≈ Median)
0 Median expression score Group median: 0 • 31.4%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

52.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.03
bar=donor   line=cohort median 		2.02 52.2%
FOXO3 Insulin/IGF-1 Signaling 10.11
bar=donor   line=cohort median 		9.99 68.6%
CETP Lipid Metabolism 4.87
bar=donor   line=cohort median 		5.05 30.3%
SIRT6 Sirtuin Family 8.25
bar=donor   line=cohort median 		8.34 28.9%
SIRT1 Sirtuin Family 8.92
bar=donor   line=cohort median 		8.72 87.3%
SIRT3 Sirtuin Family 7.36
bar=donor   line=cohort median 		7.49 27.4%
IGF1R Insulin/IGF-1 Signaling 10.56
bar=donor   line=cohort median 		10.21 86.9%
KLOTHO Anti-aging 2.89
bar=donor   line=cohort median 		2.51 90.1%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 45.7%
IL6 Inflammation 1.00
bar=donor   line=cohort median 		1.16 8.1%
TERT Telomere Maintenance 1.80
bar=donor   line=cohort median 		1.51 90.9%
IRS2 Insulin/IGF-1 Signaling 9.66
bar=donor   line=cohort median 		9.81 34.2%
TP53 Tumor Suppression 9.01
bar=donor   line=cohort median 		8.92 66.9%
SHC1 Signal Transduction 9.23
bar=donor   line=cohort median 		9.35 11.7%
ACE Signal Transduction 4.70
bar=donor   line=cohort median 		4.64 55.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.3 0
2 B2M 16.8 0
3 EEF1A1 16.8 0
4 ACTB 16.5 0
5 MT-CO1 16.4 0
6 HLA-C 16.2 0
7 MT-RNR1 15.8 0
8 HLA-E 15.6 0
9 FTL 15.6 0
10 MT-ND4 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.0
bar=donor   line=cohort median 		13.8 14.2 41.0%
2 S100A9 15.4
bar=donor   line=cohort median 		15.3 15.5 39.6%
3 IL1B 9.7
bar=donor   line=cohort median 		9.5 9.3 70.4%
4 CXCL8 10.4
bar=donor   line=cohort median 		10.6 11.4 32.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.2
bar=donor   line=cohort median 		6.0 6.1 0.9%
6 FCGR3B 15.3
bar=donor   line=cohort median 		14.6 14.7 90.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 13.8
bar=donor   line=cohort median 		14.3 14.3 8.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.3
bar=donor   line=cohort median 		10.2 10.4 46.8%
9 CD3E 12.2
bar=donor   line=cohort median 		11.9 12.0 78.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		11.0 10.9 56.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.4
bar=donor   line=cohort median 		11.7 11.7 27.8%
12 GNLY 11.8
bar=donor   line=cohort median 		12.0 12.1 29.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 37.1%
17 MT-CO2 15.1
bar=donor   line=cohort median 		15.2 15.3 18.1%
18 MT-ND1 15.0
bar=donor   line=cohort median 		15.0 15.2 18.1%
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