GSM8077493

Dataset: gse255685 • Sample: YZ490 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 28.9%ile (≈ Median)
22,338 Genes with score > 0 Group median: 22,378 • 8.6%ile (↓ Low)
0 Median expression score Group median: 0 • 8.8%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

43.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.81
bar=donor   line=cohort median 		2.02 16.3%
FOXO3 Insulin/IGF-1 Signaling 9.49
bar=donor   line=cohort median 		9.99 2.3%
CETP Lipid Metabolism 5.02
bar=donor   line=cohort median 		5.05 46.8%
SIRT6 Sirtuin Family 8.45
bar=donor   line=cohort median 		8.34 70.8%
SIRT1 Sirtuin Family 8.56
bar=donor   line=cohort median 		8.72 27.1%
SIRT3 Sirtuin Family 7.69
bar=donor   line=cohort median 		7.49 84.1%
IGF1R Insulin/IGF-1 Signaling 9.81
bar=donor   line=cohort median 		10.21 17.4%
KLOTHO Anti-aging 2.72
bar=donor   line=cohort median 		2.51 78.7%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 56.8%
IL6 Inflammation 1.00
bar=donor   line=cohort median 		1.16 10.2%
TERT Telomere Maintenance 1.88
bar=donor   line=cohort median 		1.51 95.5%
IRS2 Insulin/IGF-1 Signaling 9.23
bar=donor   line=cohort median 		9.81 6.3%
TP53 Tumor Suppression 9.03
bar=donor   line=cohort median 		8.92 70.4%
SHC1 Signal Transduction 9.28
bar=donor   line=cohort median 		9.35 26.3%
ACE Signal Transduction 4.60
bar=donor   line=cohort median 		4.64 47.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.4 0
2 B2M 16.9 0
3 EEF1A1 16.7 0
4 ACTB 16.5 0
5 MT-CO1 16.4 0
6 HLA-C 16.0 0
7 MT-RNR1 16.0 0
8 HLA-B 15.8 0
9 TMSB4X 15.7 0
10 HLA-E 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.3
bar=donor   line=cohort median 		14.2 14.2 60.4%
2 S100A9 15.5
bar=donor   line=cohort median 		15.4 15.5 48.6%
3 IL1B 9.4
bar=donor   line=cohort median 		9.5 9.3 52.9%
4 CXCL8 9.2
bar=donor   line=cohort median 		10.3 11.4 14.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.6
bar=donor   line=cohort median 		6.1 6.1 10.6%
6 FCGR3B 14.5
bar=donor   line=cohort median 		14.7 14.7 31.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 13.9
bar=donor   line=cohort median 		14.4 14.3 17.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.3
bar=donor   line=cohort median 		10.3 10.4 41.8%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 31.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.4
bar=donor   line=cohort median 		10.9 10.9 95.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.5
bar=donor   line=cohort median 		11.5 11.7 34.9%
12 GNLY 11.9
bar=donor   line=cohort median 		12.0 12.1 36.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 38.5%
17 MT-CO2 15.3
bar=donor   line=cohort median 		15.3 15.3 49.6%
18 MT-ND1 15.1
bar=donor   line=cohort median 		15.2 15.2 38.9%
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