GSM8077494

Dataset: gse255685 • Sample: YZ491 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 30.3%ile (≈ Median)
22,363 Genes with score > 0 Group median: 22,375 • 30.5%ile (≈ Median)
0 Median expression score Group median: 0 • 30.6%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

53.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.85
bar=donor   line=cohort median 		2.02 21.7%
FOXO3 Insulin/IGF-1 Signaling 10.07
bar=donor   line=cohort median 		9.99 62.2%
CETP Lipid Metabolism 5.05
bar=donor   line=cohort median 		5.05 50.7%
SIRT6 Sirtuin Family 8.34
bar=donor   line=cohort median 		8.34 51.8%
SIRT1 Sirtuin Family 8.83
bar=donor   line=cohort median 		8.72 72.9%
SIRT3 Sirtuin Family 7.17
bar=donor   line=cohort median 		7.49 5.6%
IGF1R Insulin/IGF-1 Signaling 10.70
bar=donor   line=cohort median 		10.21 94.8%
KLOTHO Anti-aging 2.53
bar=donor   line=cohort median 		2.51 53.2%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 22.4%
IL6 Inflammation 1.47
bar=donor   line=cohort median 		1.16 91.6%
TERT Telomere Maintenance 1.50
bar=donor   line=cohort median 		1.51 47.5%
IRS2 Insulin/IGF-1 Signaling 9.53
bar=donor   line=cohort median 		9.81 23.8%
TP53 Tumor Suppression 9.04
bar=donor   line=cohort median 		8.92 71.5%
SHC1 Signal Transduction 9.34
bar=donor   line=cohort median 		9.35 47.1%
ACE Signal Transduction 5.01
bar=donor   line=cohort median 		4.64 83.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.2 0
2 B2M 16.8 0
3 EEF1A1 16.7 0
4 ACTB 16.6 0
5 MT-CO1 16.3 0
6 HLA-C 16.2 0
7 HLA-E 15.7 0
8 MT-RNR1 15.6 0
9 CSF3R 15.6 0
10 HLA-B 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.0
bar=donor   line=cohort median 		13.8 14.2 37.1%
2 S100A9 15.5
bar=donor   line=cohort median 		15.3 15.5 48.2%
3 IL1B 10.1
bar=donor   line=cohort median 		9.5 9.3 91.6%
4 CXCL8 10.0
bar=donor   line=cohort median 		10.6 11.4 26.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.8
bar=donor   line=cohort median 		6.0 6.1 27.4%
6 FCGR3B 15.2
bar=donor   line=cohort median 		14.6 14.7 84.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.2
bar=donor   line=cohort median 		14.3 14.3 40.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.1
bar=donor   line=cohort median 		10.2 10.4 17.4%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 37.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.0
bar=donor   line=cohort median 		11.0 10.9 64.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.8
bar=donor   line=cohort median 		11.7 11.7 54.3%
12 GNLY 12.3
bar=donor   line=cohort median 		12.0 12.1 61.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 22.8%
17 MT-CO2 14.8
bar=donor   line=cohort median 		15.2 15.3 3.4%
18 MT-ND1 14.7
bar=donor   line=cohort median 		15.0 15.2 4.8%
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