GSM8077495

Dataset: gse255685 • Sample: YZ494 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 48.6%ile (≈ Median)
22,404 Genes with score > 0 Group median: 22,378 • 76.5%ile (↑ High)
0 Median expression score Group median: 0 • 55.4%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

42.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.97
bar=donor   line=cohort median 		2.02 42.1%
FOXO3 Insulin/IGF-1 Signaling 9.64
bar=donor   line=cohort median 		9.99 9.9%
CETP Lipid Metabolism 4.99
bar=donor   line=cohort median 		5.05 43.6%
SIRT6 Sirtuin Family 8.11
bar=donor   line=cohort median 		8.34 5.9%
SIRT1 Sirtuin Family 8.82
bar=donor   line=cohort median 		8.72 70.1%
SIRT3 Sirtuin Family 7.66
bar=donor   line=cohort median 		7.49 80.1%
IGF1R Insulin/IGF-1 Signaling 10.20
bar=donor   line=cohort median 		10.21 48.9%
KLOTHO Anti-aging 2.33
bar=donor   line=cohort median 		2.51 23.1%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 52.5%
IL6 Inflammation 1.26
bar=donor   line=cohort median 		1.16 67.9%
TERT Telomere Maintenance 1.54
bar=donor   line=cohort median 		1.51 56.1%
IRS2 Insulin/IGF-1 Signaling 9.31
bar=donor   line=cohort median 		9.81 8.8%
TP53 Tumor Suppression 9.02
bar=donor   line=cohort median 		8.92 67.6%
SHC1 Signal Transduction 9.33
bar=donor   line=cohort median 		9.35 42.8%
ACE Signal Transduction 4.27
bar=donor   line=cohort median 		4.64 13.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.4 0
2 B2M 16.7 0
3 EEF1A1 16.7 0
4 ACTB 16.4 0
5 MT-CO1 16.4 0
6 MT-RNR1 15.8 0
7 HLA-B 15.7 0
8 HLA-C 15.6 0
9 S100A9 15.6 0
10 MT-ND4 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.6
bar=donor   line=cohort median 		14.2 14.2 75.1%
2 S100A9 15.6
bar=donor   line=cohort median 		15.4 15.5 52.5%
3 IL1B 9.8
bar=donor   line=cohort median 		9.5 9.3 75.8%
4 CXCL8 10.3
bar=donor   line=cohort median 		10.3 11.4 30.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.0
bar=donor   line=cohort median 		6.1 6.1 46.8%
6 FCGR3B 14.2
bar=donor   line=cohort median 		14.7 14.7 16.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 13.6
bar=donor   line=cohort median 		14.4 14.3 4.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.5
bar=donor   line=cohort median 		10.3 10.4 68.3%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 49.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.2
bar=donor   line=cohort median 		10.9 10.9 79.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.8
bar=donor   line=cohort median 		11.5 11.7 56.5%
12 GNLY 12.3
bar=donor   line=cohort median 		12.0 12.1 63.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 34.6%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.3 15.3 60.4%
18 MT-ND1 15.0
bar=donor   line=cohort median 		15.2 15.2 19.5%
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