GSM8077496

Dataset: gse255685 • Sample: YZ496 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 16.3%ile (↓ Low)
22,363 Genes with score > 0 Group median: 22,378 • 30.5%ile (≈ Median)
0 Median expression score Group median: 0 • 37.1%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

40.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.89
bar=donor   line=cohort median 		2.02 28.1%
FOXO3 Insulin/IGF-1 Signaling 9.53
bar=donor   line=cohort median 		9.99 3.8%
CETP Lipid Metabolism 5.33
bar=donor   line=cohort median 		5.05 81.5%
SIRT6 Sirtuin Family 8.33
bar=donor   line=cohort median 		8.34 49.3%
SIRT1 Sirtuin Family 8.58
bar=donor   line=cohort median 		8.72 31.7%
SIRT3 Sirtuin Family 7.59
bar=donor   line=cohort median 		7.49 66.9%
IGF1R Insulin/IGF-1 Signaling 9.92
bar=donor   line=cohort median 		10.21 25.6%
KLOTHO Anti-aging 2.25
bar=donor   line=cohort median 		2.51 12.7%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 49.3%
IL6 Inflammation 1.09
bar=donor   line=cohort median 		1.16 31.7%
TERT Telomere Maintenance 1.54
bar=donor   line=cohort median 		1.51 55.0%
IRS2 Insulin/IGF-1 Signaling 9.13
bar=donor   line=cohort median 		9.81 2.7%
TP53 Tumor Suppression 9.01
bar=donor   line=cohort median 		8.92 64.7%
SHC1 Signal Transduction 9.35
bar=donor   line=cohort median 		9.35 51.1%
ACE Signal Transduction 4.68
bar=donor   line=cohort median 		4.64 53.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.3 0
2 B2M 16.9 0
3 EEF1A1 16.7 0
4 MT-CO1 16.4 0
5 ACTB 16.3 0
6 HLA-C 16.1 0
7 HLA-B 15.9 0
8 MT-RNR1 15.8 0
9 MT-ND4 15.7 0
10 HLA-E 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.1
bar=donor   line=cohort median 		14.2 14.2 45.0%
2 S100A9 15.1
bar=donor   line=cohort median 		15.4 15.5 21.0%
3 IL1B 9.3
bar=donor   line=cohort median 		9.5 9.3 49.3%
4 CXCL8 9.6
bar=donor   line=cohort median 		10.3 11.4 19.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.1
bar=donor   line=cohort median 		6.1 6.1 57.2%
6 FCGR3B 14.4
bar=donor   line=cohort median 		14.7 14.7 26.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.1
bar=donor   line=cohort median 		14.4 14.3 27.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.7
bar=donor   line=cohort median 		10.3 10.4 85.1%
9 CD3E 12.2
bar=donor   line=cohort median 		11.9 12.0 76.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.0
bar=donor   line=cohort median 		10.9 10.9 64.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.1
bar=donor   line=cohort median 		11.5 11.7 76.5%
12 GNLY 12.5
bar=donor   line=cohort median 		12.0 12.1 74.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 53.6%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.3 15.3 56.1%
18 MT-ND1 15.1
bar=donor   line=cohort median 		15.2 15.2 35.3%
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