GSM8077497

Dataset: gse255685 • Sample: YZ497 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 56.8%ile (≈ Median)
22,361 Genes with score > 0 Group median: 22,378 • 27.4%ile (≈ Median)
0 Median expression score Group median: 0 • 34.2%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

51.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.22
bar=donor   line=cohort median 		2.02 78.3%
FOXO3 Insulin/IGF-1 Signaling 9.85
bar=donor   line=cohort median 		9.99 29.9%
CETP Lipid Metabolism 5.52
bar=donor   line=cohort median 		5.05 91.9%
SIRT6 Sirtuin Family 8.31
bar=donor   line=cohort median 		8.34 40.7%
SIRT1 Sirtuin Family 8.93
bar=donor   line=cohort median 		8.72 88.4%
SIRT3 Sirtuin Family 7.57
bar=donor   line=cohort median 		7.49 64.0%
IGF1R Insulin/IGF-1 Signaling 9.83
bar=donor   line=cohort median 		10.21 18.5%
KLOTHO Anti-aging 2.47
bar=donor   line=cohort median 		2.51 46.4%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 20.6%
IL6 Inflammation 1.28
bar=donor   line=cohort median 		1.16 74.7%
TERT Telomere Maintenance 1.56
bar=donor   line=cohort median 		1.51 61.1%
IRS2 Insulin/IGF-1 Signaling 9.16
bar=donor   line=cohort median 		9.81 4.8%
TP53 Tumor Suppression 9.12
bar=donor   line=cohort median 		8.92 81.9%
SHC1 Signal Transduction 9.25
bar=donor   line=cohort median 		9.35 17.7%
ACE Signal Transduction 4.58
bar=donor   line=cohort median 		4.64 45.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.1 0
2 B2M 16.9 0
3 EEF1A1 16.6 0
4 ACTB 16.2 0
5 HLA-C 16.1 0
6 MT-CO1 16.1 0
7 HLA-B 15.9 0
8 HLA-E 15.7 0
9 MT-RNR1 15.7 0
10 UBA52 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.8
bar=donor   line=cohort median 		14.2 14.2 28.5%
2 S100A9 15.2
bar=donor   line=cohort median 		15.4 15.5 22.8%
3 IL1B 9.2
bar=donor   line=cohort median 		9.5 9.3 43.9%
4 CXCL8 10.7
bar=donor   line=cohort median 		10.3 11.4 35.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.0
bar=donor   line=cohort median 		6.1 6.1 47.1%
6 FCGR3B 15.2
bar=donor   line=cohort median 		14.7 14.7 84.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.0
bar=donor   line=cohort median 		14.4 14.3 23.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.4
bar=donor   line=cohort median 		10.3 10.4 54.7%
9 CD3E 12.1
bar=donor   line=cohort median 		11.9 12.0 65.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.3
bar=donor   line=cohort median 		10.9 10.9 91.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.0
bar=donor   line=cohort median 		11.5 11.7 71.5%
12 GNLY 12.2
bar=donor   line=cohort median 		12.0 12.1 59.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.1
bar=donor   line=cohort median 		16.4 16.4 3.4%
17 MT-CO2 15.1
bar=donor   line=cohort median 		15.3 15.3 21.3%
18 MT-ND1 14.9
bar=donor   line=cohort median 		15.2 15.2 13.4%
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