GSM8077499

Dataset: gse255685 • Sample: YZ504 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 98.7%ile (↑ High)
22,448 Genes with score > 0 Group median: 22,378 • 97.3%ile (↑ High)
0 Median expression score Group median: 0 • 98.4%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

49.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.72
bar=donor   line=cohort median 		2.02 3.1%
FOXO3 Insulin/IGF-1 Signaling 10.30
bar=donor   line=cohort median 		9.99 91.2%
CETP Lipid Metabolism 4.95
bar=donor   line=cohort median 		5.05 38.5%
SIRT6 Sirtuin Family 8.16
bar=donor   line=cohort median 		8.34 14.2%
SIRT1 Sirtuin Family 8.67
bar=donor   line=cohort median 		8.72 45.0%
SIRT3 Sirtuin Family 7.65
bar=donor   line=cohort median 		7.49 77.2%
IGF1R Insulin/IGF-1 Signaling 10.45
bar=donor   line=cohort median 		10.21 76.9%
KLOTHO Anti-aging 2.35
bar=donor   line=cohort median 		2.51 25.6%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 58.2%
IL6 Inflammation 1.34
bar=donor   line=cohort median 		1.16 83.3%
TERT Telomere Maintenance 1.82
bar=donor   line=cohort median 		1.51 91.9%
IRS2 Insulin/IGF-1 Signaling 10.65
bar=donor   line=cohort median 		9.81 89.1%
TP53 Tumor Suppression 8.37
bar=donor   line=cohort median 		8.92 2.3%
SHC1 Signal Transduction 9.16
bar=donor   line=cohort median 		9.35 5.6%
ACE Signal Transduction 4.48
bar=donor   line=cohort median 		4.64 35.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.8 0
2 B2M 17.0 0
3 EEF1A1 16.7 0
4 MT-RNR1 16.3 0
5 MT-CO1 16.3 0
6 ACTB 16.1 0
7 HLA-C 16.1 0
8 TXNIP 15.8 0
9 MT-ND4 15.8 0
10 HLA-E 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.2
bar=donor   line=cohort median 		14.2 14.2 51.1%
2 S100A9 15.3
bar=donor   line=cohort median 		15.4 15.5 34.6%
3 IL1B 7.7
bar=donor   line=cohort median 		9.5 9.3 2.3%
4 CXCL8 10.0
bar=donor   line=cohort median 		10.3 11.4 27.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.8
bar=donor   line=cohort median 		6.1 6.1 28.1%
6 FCGR3B 14.7
bar=donor   line=cohort median 		14.7 14.7 52.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.4
bar=donor   line=cohort median 		14.4 14.3 52.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.2
bar=donor   line=cohort median 		10.3 10.4 33.5%
9 CD3E 11.7
bar=donor   line=cohort median 		11.9 12.0 12.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.2
bar=donor   line=cohort median 		10.9 10.9 77.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.2
bar=donor   line=cohort median 		11.5 11.7 12.4%
12 GNLY 12.1
bar=donor   line=cohort median 		12.0 12.1 44.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 21.0%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.3 15.3 59.0%
18 MT-ND1 15.5
bar=donor   line=cohort median 		15.2 15.2 83.0%
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