GSM8077503

Dataset: gse255685 • Sample: YZ509 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 19.2%ile (↓ Low)
22,345 Genes with score > 0 Group median: 22,378 • 11.6%ile (↓ Low)
0 Median expression score Group median: 0 • 26.0%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

45.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.82
bar=donor   line=cohort median 		2.02 17.4%
FOXO3 Insulin/IGF-1 Signaling 9.79
bar=donor   line=cohort median 		9.99 23.8%
CETP Lipid Metabolism 5.17
bar=donor   line=cohort median 		5.05 67.6%
SIRT6 Sirtuin Family 8.33
bar=donor   line=cohort median 		8.34 48.2%
SIRT1 Sirtuin Family 8.82
bar=donor   line=cohort median 		8.72 72.2%
SIRT3 Sirtuin Family 7.05
bar=donor   line=cohort median 		7.49 2.0%
IGF1R Insulin/IGF-1 Signaling 10.33
bar=donor   line=cohort median 		10.21 63.6%
KLOTHO Anti-aging 2.63
bar=donor   line=cohort median 		2.51 67.2%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 61.8%
IL6 Inflammation 1.27
bar=donor   line=cohort median 		1.16 70.4%
TERT Telomere Maintenance 1.56
bar=donor   line=cohort median 		1.51 59.7%
IRS2 Insulin/IGF-1 Signaling 9.31
bar=donor   line=cohort median 		9.81 9.5%
TP53 Tumor Suppression 9.12
bar=donor   line=cohort median 		8.92 82.3%
SHC1 Signal Transduction 9.31
bar=donor   line=cohort median 		9.35 36.0%
ACE Signal Transduction 4.04
bar=donor   line=cohort median 		4.64 2.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.9 0
2 B2M 17.0 0
3 EEF1A1 16.7 0
4 ACTB 16.6 0
5 MT-CO1 16.5 0
6 MT-RNR1 16.3 0
7 HLA-C 16.3 0
8 HLA-B 16.0 0
9 S100A9 15.9 0
10 TMSB4X 15.8 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 15.0
bar=donor   line=cohort median 		14.2 14.2 92.3%
2 S100A9 15.9
bar=donor   line=cohort median 		15.4 15.5 75.4%
3 IL1B 10.1
bar=donor   line=cohort median 		9.5 9.3 88.4%
4 CXCL8 10.1
bar=donor   line=cohort median 		10.3 11.4 28.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.5
bar=donor   line=cohort median 		6.1 6.1 71.9%
6 FCGR3B 15.3
bar=donor   line=cohort median 		14.7 14.7 91.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.6
bar=donor   line=cohort median 		14.4 14.3 71.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.6
bar=donor   line=cohort median 		10.3 10.4 78.7%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 43.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.8
bar=donor   line=cohort median 		10.9 10.9 31.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.8
bar=donor   line=cohort median 		11.5 11.7 60.8%
12 GNLY 12.6
bar=donor   line=cohort median 		12.0 12.1 79.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 72.6%
17 MT-CO2 15.3
bar=donor   line=cohort median 		15.3 15.3 51.8%
18 MT-ND1 15.6
bar=donor   line=cohort median 		15.2 15.2 87.6%
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