GSM8077505

Dataset: gse255685 • Sample: YZ517 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 40.3%ile (≈ Median)
22,352 Genes with score > 0 Group median: 22,378 • 16.5%ile (↓ Low)
0 Median expression score Group median: 0 • 17.7%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

52.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.31
bar=donor   line=cohort median 		2.02 83.3%
FOXO3 Insulin/IGF-1 Signaling 9.65
bar=donor   line=cohort median 		9.99 10.2%
CETP Lipid Metabolism 5.29
bar=donor   line=cohort median 		5.05 79.0%
SIRT6 Sirtuin Family 8.48
bar=donor   line=cohort median 		8.34 74.0%
SIRT1 Sirtuin Family 8.58
bar=donor   line=cohort median 		8.72 30.3%
SIRT3 Sirtuin Family 7.67
bar=donor   line=cohort median 		7.49 80.8%
IGF1R Insulin/IGF-1 Signaling 9.72
bar=donor   line=cohort median 		10.21 11.7%
KLOTHO Anti-aging 2.73
bar=donor   line=cohort median 		2.51 79.0%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 72.9%
IL6 Inflammation 1.30
bar=donor   line=cohort median 		1.16 76.2%
TERT Telomere Maintenance 1.58
bar=donor   line=cohort median 		1.51 65.1%
IRS2 Insulin/IGF-1 Signaling 9.15
bar=donor   line=cohort median 		9.81 4.5%
TP53 Tumor Suppression 9.15
bar=donor   line=cohort median 		8.92 87.3%
SHC1 Signal Transduction 9.22
bar=donor   line=cohort median 		9.35 10.6%
ACE Signal Transduction 4.38
bar=donor   line=cohort median 		4.64 23.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 18.0 0
2 B2M 17.1 0
3 EEF1A1 16.8 0
4 ACTB 16.6 0
5 MT-CO1 16.5 0
6 MT-RNR1 16.5 0
7 HLA-C 16.3 0
8 HLA-B 16.1 0
9 S100A9 16.0 0
10 TMSB4X 15.9 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.8
bar=donor   line=cohort median 		14.2 14.2 86.6%
2 S100A9 16.0
bar=donor   line=cohort median 		15.4 15.5 78.3%
3 IL1B 9.9
bar=donor   line=cohort median 		9.5 9.3 81.5%
4 CXCL8 10.3
bar=donor   line=cohort median 		10.3 11.4 31.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.3
bar=donor   line=cohort median 		6.1 6.1 65.8%
6 FCGR3B 15.0
bar=donor   line=cohort median 		14.7 14.7 71.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.7
bar=donor   line=cohort median 		14.4 14.3 82.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.7
bar=donor   line=cohort median 		10.3 10.4 83.3%
9 CD3E 12.2
bar=donor   line=cohort median 		11.9 12.0 86.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		10.9 10.9 53.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.8
bar=donor   line=cohort median 		11.5 11.7 59.0%
12 GNLY 12.5
bar=donor   line=cohort median 		12.0 12.1 77.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 69.7%
17 MT-CO2 15.6
bar=donor   line=cohort median 		15.3 15.3 82.6%
18 MT-ND1 15.4
bar=donor   line=cohort median 		15.2 15.2 78.0%
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