GSM8077506

Dataset: gse255685 • Sample: YZ523 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 75.8%ile (↑ High)
22,424 Genes with score > 0 Group median: 22,378 • 91.4%ile (↑ High)
0 Median expression score Group median: 0 • 86.2%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

50.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.28
bar=donor   line=cohort median 		2.02 80.8%
FOXO3 Insulin/IGF-1 Signaling 10.05
bar=donor   line=cohort median 		9.99 57.2%
CETP Lipid Metabolism 4.83
bar=donor   line=cohort median 		5.05 24.9%
SIRT6 Sirtuin Family 8.26
bar=donor   line=cohort median 		8.34 31.0%
SIRT1 Sirtuin Family 8.65
bar=donor   line=cohort median 		8.72 42.1%
SIRT3 Sirtuin Family 7.60
bar=donor   line=cohort median 		7.49 68.6%
IGF1R Insulin/IGF-1 Signaling 10.18
bar=donor   line=cohort median 		10.21 47.1%
KLOTHO Anti-aging 2.32
bar=donor   line=cohort median 		2.51 20.6%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 43.2%
IL6 Inflammation 1.25
bar=donor   line=cohort median 		1.16 66.9%
TERT Telomere Maintenance 1.90
bar=donor   line=cohort median 		1.51 96.6%
IRS2 Insulin/IGF-1 Signaling 10.83
bar=donor   line=cohort median 		9.81 94.8%
TP53 Tumor Suppression 8.53
bar=donor   line=cohort median 		8.92 11.7%
SHC1 Signal Transduction 9.30
bar=donor   line=cohort median 		9.35 34.2%
ACE Signal Transduction 4.45
bar=donor   line=cohort median 		4.64 31.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.3 0
2 EEF1A1 16.8 0
3 B2M 16.7 0
4 MT-CO1 16.3 0
5 ACTB 16.2 0
6 HLA-B 15.9 0
7 MT-RNR1 15.7 0
8 HLA-C 15.6 0
9 TXNIP 15.6 0
10 HLA-E 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.1
bar=donor   line=cohort median 		14.2 14.2 45.7%
2 S100A9 15.2
bar=donor   line=cohort median 		15.4 15.5 26.7%
3 IL1B 8.2
bar=donor   line=cohort median 		9.5 9.3 7.7%
4 CXCL8 12.7
bar=donor   line=cohort median 		10.3 11.4 88.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.4
bar=donor   line=cohort median 		6.1 6.1 66.5%
6 FCGR3B 13.7
bar=donor   line=cohort median 		14.7 14.7 4.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.3
bar=donor   line=cohort median 		14.4 14.3 50.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.3
bar=donor   line=cohort median 		10.3 10.4 46.4%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 28.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.0
bar=donor   line=cohort median 		10.9 10.9 68.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.1
bar=donor   line=cohort median 		11.5 11.7 6.3%
12 GNLY 11.7
bar=donor   line=cohort median 		12.0 12.1 19.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 22.0%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.3 15.3 53.6%
18 MT-ND1 15.0
bar=donor   line=cohort median 		15.2 15.2 24.6%
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