GSM8077507

Dataset: gse255685 • Sample: YZ524 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 78.3%ile (↑ High)
22,424 Genes with score > 0 Group median: 22,378 • 91.4%ile (↑ High)
0 Median expression score Group median: 0 • 78.0%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

44.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.01
bar=donor   line=cohort median 		2.02 49.3%
FOXO3 Insulin/IGF-1 Signaling 9.69
bar=donor   line=cohort median 		9.99 13.1%
CETP Lipid Metabolism 5.00
bar=donor   line=cohort median 		5.05 43.9%
SIRT6 Sirtuin Family 8.26
bar=donor   line=cohort median 		8.34 32.1%
SIRT1 Sirtuin Family 8.32
bar=donor   line=cohort median 		8.72 7.4%
SIRT3 Sirtuin Family 7.94
bar=donor   line=cohort median 		7.49 99.5%
IGF1R Insulin/IGF-1 Signaling 9.82
bar=donor   line=cohort median 		10.21 17.7%
KLOTHO Anti-aging 2.38
bar=donor   line=cohort median 		2.51 31.4%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 74.4%
IL6 Inflammation 1.11
bar=donor   line=cohort median 		1.16 37.5%
TERT Telomere Maintenance 1.66
bar=donor   line=cohort median 		1.51 79.4%
IRS2 Insulin/IGF-1 Signaling 9.59
bar=donor   line=cohort median 		9.81 28.9%
TP53 Tumor Suppression 8.78
bar=donor   line=cohort median 		8.92 35.3%
SHC1 Signal Transduction 9.36
bar=donor   line=cohort median 		9.35 55.7%
ACE Signal Transduction 4.71
bar=donor   line=cohort median 		4.64 57.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.4 0
2 EEF1A1 17.0 0
3 B2M 16.8 0
4 MT-CO1 16.4 0
5 ACTB 16.4 0
6 HLA-C 16.2 0
7 MT-ND4 15.9 0
8 MT-RNR1 15.7 0
9 TMSB4X 15.7 0
10 S100A9 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.6
bar=donor   line=cohort median 		14.2 14.2 74.4%
2 S100A9 15.7
bar=donor   line=cohort median 		15.4 15.5 62.5%
3 IL1B 8.1
bar=donor   line=cohort median 		9.5 9.3 5.9%
4 CXCL8 10.8
bar=donor   line=cohort median 		10.3 11.4 39.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.9
bar=donor   line=cohort median 		6.1 6.1 85.8%
6 FCGR3B 14.1
bar=donor   line=cohort median 		14.7 14.7 12.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.6
bar=donor   line=cohort median 		14.4 14.3 67.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.7
bar=donor   line=cohort median 		10.3 10.4 86.2%
9 CD3E 12.2
bar=donor   line=cohort median 		11.9 12.0 84.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.1
bar=donor   line=cohort median 		10.9 10.9 76.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.1
bar=donor   line=cohort median 		11.5 11.7 8.4%
12 GNLY 11.7
bar=donor   line=cohort median 		12.0 12.1 17.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 44.6%
17 MT-CO2 15.6
bar=donor   line=cohort median 		15.3 15.3 79.4%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.2 15.2 65.4%
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