GSM8077508

Dataset: gse255685 • Sample: YZ525 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 39.2%ile (≈ Median)
22,402 Genes with score > 0 Group median: 22,378 • 74.9%ile (≈ Median)
0 Median expression score Group median: 0 • 80.5%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

40.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.02
bar=donor   line=cohort median 		2.02 50.0%
FOXO3 Insulin/IGF-1 Signaling 9.80
bar=donor   line=cohort median 		9.99 24.9%
CETP Lipid Metabolism 5.30
bar=donor   line=cohort median 		5.05 80.1%
SIRT6 Sirtuin Family 8.14
bar=donor   line=cohort median 		8.34 9.5%
SIRT1 Sirtuin Family 8.86
bar=donor   line=cohort median 		8.72 76.9%
SIRT3 Sirtuin Family 7.45
bar=donor   line=cohort median 		7.49 41.0%
IGF1R Insulin/IGF-1 Signaling 9.87
bar=donor   line=cohort median 		10.21 22.0%
KLOTHO Anti-aging 2.44
bar=donor   line=cohort median 		2.51 40.0%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 11.3%
IL6 Inflammation 1.06
bar=donor   line=cohort median 		1.16 20.6%
TERT Telomere Maintenance 1.54
bar=donor   line=cohort median 		1.51 56.5%
IRS2 Insulin/IGF-1 Signaling 9.15
bar=donor   line=cohort median 		9.81 4.1%
TP53 Tumor Suppression 9.01
bar=donor   line=cohort median 		8.92 64.3%
SHC1 Signal Transduction 9.31
bar=donor   line=cohort median 		9.35 37.8%
ACE Signal Transduction 4.78
bar=donor   line=cohort median 		4.64 64.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.5 0
2 B2M 16.7 0
3 EEF1A1 16.6 0
4 MT-CO1 16.4 0
5 ACTB 16.3 0
6 MT-RNR1 16.1 0
7 MT-ND4 15.7 0
8 HLA-C 15.6 0
9 HLA-B 15.6 0
10 HLA-E 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.3
bar=donor   line=cohort median 		14.2 14.2 58.6%
2 S100A9 15.4
bar=donor   line=cohort median 		15.4 15.5 37.5%
3 IL1B 9.3
bar=donor   line=cohort median 		9.5 9.3 46.1%
4 CXCL8 10.3
bar=donor   line=cohort median 		10.3 11.4 31.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.5
bar=donor   line=cohort median 		6.1 6.1 8.4%
6 FCGR3B 14.6
bar=donor   line=cohort median 		14.7 14.7 40.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.2
bar=donor   line=cohort median 		14.4 14.3 41.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.5
bar=donor   line=cohort median 		10.3 10.4 66.8%
9 CD3E 12.1
bar=donor   line=cohort median 		11.9 12.0 66.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.7
bar=donor   line=cohort median 		10.9 10.9 26.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.4
bar=donor   line=cohort median 		11.5 11.7 21.0%
12 GNLY 12.2
bar=donor   line=cohort median 		12.0 12.1 60.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 50.7%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.3 15.3 61.8%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.2 15.2 63.3%
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