GSM8077509

Dataset: gse255685 • Sample: YZ526 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 59.0%ile (≈ Median)
22,389 Genes with score > 0 Group median: 22,378 • 66.5%ile (≈ Median)
0 Median expression score Group median: 0 • 57.9%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

49.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.82
bar=donor   line=cohort median 		2.02 17.0%
FOXO3 Insulin/IGF-1 Signaling 10.18
bar=donor   line=cohort median 		9.99 80.8%
CETP Lipid Metabolism 4.97
bar=donor   line=cohort median 		5.05 41.8%
SIRT6 Sirtuin Family 8.36
bar=donor   line=cohort median 		8.34 57.9%
SIRT1 Sirtuin Family 8.63
bar=donor   line=cohort median 		8.72 38.5%
SIRT3 Sirtuin Family 7.72
bar=donor   line=cohort median 		7.49 86.2%
IGF1R Insulin/IGF-1 Signaling 10.06
bar=donor   line=cohort median 		10.21 35.3%
KLOTHO Anti-aging 2.27
bar=donor   line=cohort median 		2.51 14.5%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 61.5%
IL6 Inflammation 1.00
bar=donor   line=cohort median 		1.16 12.4%
TERT Telomere Maintenance 1.47
bar=donor   line=cohort median 		1.51 42.8%
IRS2 Insulin/IGF-1 Signaling 10.76
bar=donor   line=cohort median 		9.81 92.3%
TP53 Tumor Suppression 8.54
bar=donor   line=cohort median 		8.92 13.4%
SHC1 Signal Transduction 9.49
bar=donor   line=cohort median 		9.35 85.5%
ACE Signal Transduction 4.69
bar=donor   line=cohort median 		4.64 54.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.7 0
2 B2M 17.1 0
3 EEF1A1 16.6 0
4 ACTB 16.6 0
5 MT-CO1 16.5 0
6 MT-RNR1 16.3 0
7 HLA-B 16.2 0
8 HLA-C 16.1 0
9 S100A9 16.0 0
10 FTL 16.0 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.9
bar=donor   line=cohort median 		14.2 14.2 88.0%
2 S100A9 16.0
bar=donor   line=cohort median 		15.4 15.5 79.4%
3 IL1B 8.4
bar=donor   line=cohort median 		9.5 9.3 13.8%
4 CXCL8 10.6
bar=donor   line=cohort median 		10.3 11.4 35.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.5
bar=donor   line=cohort median 		6.1 6.1 74.0%
6 FCGR3B 14.7
bar=donor   line=cohort median 		14.7 14.7 53.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.6
bar=donor   line=cohort median 		14.4 14.3 71.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.4
bar=donor   line=cohort median 		10.3 10.4 58.2%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 31.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.5
bar=donor   line=cohort median 		10.9 10.9 12.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.3
bar=donor   line=cohort median 		11.5 11.7 83.0%
12 GNLY 12.8
bar=donor   line=cohort median 		12.0 12.1 88.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 72.9%
17 MT-CO2 15.5
bar=donor   line=cohort median 		15.3 15.3 77.6%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.2 15.2 69.7%
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