GSM8077510

Dataset: gse255685 • Sample: YZ533 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 43.5%ile (≈ Median)
22,363 Genes with score > 0 Group median: 22,375 • 30.5%ile (≈ Median)
0 Median expression score Group median: 0 • 27.8%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

46.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.90
bar=donor   line=cohort median 		2.02 31.7%
FOXO3 Insulin/IGF-1 Signaling 10.10
bar=donor   line=cohort median 		9.99 67.9%
CETP Lipid Metabolism 4.87
bar=donor   line=cohort median 		5.05 31.0%
SIRT6 Sirtuin Family 8.34
bar=donor   line=cohort median 		8.34 52.9%
SIRT1 Sirtuin Family 8.73
bar=donor   line=cohort median 		8.72 52.5%
SIRT3 Sirtuin Family 7.39
bar=donor   line=cohort median 		7.49 33.2%
IGF1R Insulin/IGF-1 Signaling 10.17
bar=donor   line=cohort median 		10.21 45.3%
KLOTHO Anti-aging 2.42
bar=donor   line=cohort median 		2.51 37.8%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 58.6%
IL6 Inflammation 1.00
bar=donor   line=cohort median 		1.16 11.3%
TERT Telomere Maintenance 1.55
bar=donor   line=cohort median 		1.51 57.9%
IRS2 Insulin/IGF-1 Signaling 10.47
bar=donor   line=cohort median 		9.81 82.3%
TP53 Tumor Suppression 8.81
bar=donor   line=cohort median 		8.92 41.0%
SHC1 Signal Transduction 9.44
bar=donor   line=cohort median 		9.35 76.9%
ACE Signal Transduction 4.22
bar=donor   line=cohort median 		4.64 9.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.6 0
2 EEF1A1 17.1 0
3 MT-CO1 16.9 0
4 B2M 16.8 0
5 ACTB 16.7 0
6 MT-RNR1 16.4 0
7 MT-ND4 16.1 0
8 TXNIP 15.9 0
9 HLA-B 15.9 0
10 HLA-C 15.9 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.7
bar=donor   line=cohort median 		13.8 14.2 23.1%
2 S100A9 15.4
bar=donor   line=cohort median 		15.3 15.5 40.7%
3 IL1B 8.1
bar=donor   line=cohort median 		9.5 9.3 4.8%
4 CXCL8 12.0
bar=donor   line=cohort median 		10.6 11.4 70.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.4
bar=donor   line=cohort median 		6.0 6.1 70.1%
6 FCGR3B 14.5
bar=donor   line=cohort median 		14.6 14.7 33.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.7
bar=donor   line=cohort median 		14.3 14.3 79.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.4
bar=donor   line=cohort median 		10.2 10.4 56.5%
9 CD3E 12.2
bar=donor   line=cohort median 		11.9 12.0 80.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.0
bar=donor   line=cohort median 		11.0 10.9 65.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.4
bar=donor   line=cohort median 		11.7 11.7 29.2%
12 GNLY 11.5
bar=donor   line=cohort median 		12.0 12.1 9.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.9
bar=donor   line=cohort median 		16.4 16.4 97.0%
17 MT-CO2 15.7
bar=donor   line=cohort median 		15.2 15.3 85.5%
18 MT-ND1 15.6
bar=donor   line=cohort median 		15.0 15.2 86.9%
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