GSM8077511

Dataset: gse255685 • Sample: YZ535 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 72.6%ile (≈ Median)
22,412 Genes with score > 0 Group median: 22,375 • 86.4%ile (↑ High)
0 Median expression score Group median: 0 • 81.9%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

37.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.11
bar=donor   line=cohort median 		2.02 66.5%
FOXO3 Insulin/IGF-1 Signaling 10.18
bar=donor   line=cohort median 		9.99 81.5%
CETP Lipid Metabolism 4.57
bar=donor   line=cohort median 		5.05 4.1%
SIRT6 Sirtuin Family 8.26
bar=donor   line=cohort median 		8.34 31.4%
SIRT1 Sirtuin Family 8.50
bar=donor   line=cohort median 		8.72 20.6%
SIRT3 Sirtuin Family 7.31
bar=donor   line=cohort median 		7.49 19.5%
IGF1R Insulin/IGF-1 Signaling 9.73
bar=donor   line=cohort median 		10.21 12.4%
KLOTHO Anti-aging 2.77
bar=donor   line=cohort median 		2.51 83.3%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 5.2%
IL6 Inflammation 0.97
bar=donor   line=cohort median 		1.16 1.3%
TERT Telomere Maintenance 1.64
bar=donor   line=cohort median 		1.51 76.5%
IRS2 Insulin/IGF-1 Signaling 10.90
bar=donor   line=cohort median 		9.81 95.9%
TP53 Tumor Suppression 8.72
bar=donor   line=cohort median 		8.92 28.9%
SHC1 Signal Transduction 9.30
bar=donor   line=cohort median 		9.35 34.6%
ACE Signal Transduction 4.10
bar=donor   line=cohort median 		4.64 4.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 16.9 0
2 B2M 16.8 0
3 EEF1A1 16.8 0
4 ACTB 16.4 0
5 MT-CO1 16.2 0
6 HLA-C 15.9 0
7 TXNIP 15.7 0
8 HLA-E 15.7 0
9 HLA-B 15.6 0
10 MT-RNR1 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.4
bar=donor   line=cohort median 		13.8 14.2 14.5%
2 S100A9 15.2
bar=donor   line=cohort median 		15.3 15.5 25.6%
3 IL1B 8.2
bar=donor   line=cohort median 		9.5 9.3 8.1%
4 CXCL8 12.1
bar=donor   line=cohort median 		10.6 11.4 71.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.5
bar=donor   line=cohort median 		6.0 6.1 6.3%
6 FCGR3B 14.4
bar=donor   line=cohort median 		14.6 14.7 24.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.7
bar=donor   line=cohort median 		14.3 14.3 81.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.1
bar=donor   line=cohort median 		10.2 10.4 18.5%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 39.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.1
bar=donor   line=cohort median 		11.0 10.9 73.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.0
bar=donor   line=cohort median 		11.7 11.7 69.0%
12 GNLY 12.4
bar=donor   line=cohort median 		12.0 12.1 73.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.2
bar=donor   line=cohort median 		16.4 16.4 9.5%
17 MT-CO2 15.0
bar=donor   line=cohort median 		15.2 15.3 12.4%
18 MT-ND1 14.9
bar=donor   line=cohort median 		15.0 15.2 12.4%
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