GSM8077512

Dataset: gse255685 • Sample: YZ536 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 20.6%ile (↓ Low)
22,382 Genes with score > 0 Group median: 22,378 • 57.0%ile (≈ Median)
0 Median expression score Group median: 0 • 51.8%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

51.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.98
bar=donor   line=cohort median 		2.02 43.2%
FOXO3 Insulin/IGF-1 Signaling 9.50
bar=donor   line=cohort median 		9.99 2.7%
CETP Lipid Metabolism 5.07
bar=donor   line=cohort median 		5.05 53.9%
SIRT6 Sirtuin Family 8.18
bar=donor   line=cohort median 		8.34 16.7%
SIRT1 Sirtuin Family 8.99
bar=donor   line=cohort median 		8.72 92.7%
SIRT3 Sirtuin Family 7.60
bar=donor   line=cohort median 		7.49 70.1%
IGF1R Insulin/IGF-1 Signaling 9.84
bar=donor   line=cohort median 		10.21 19.2%
KLOTHO Anti-aging 3.09
bar=donor   line=cohort median 		2.51 98.8%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 57.2%
IL6 Inflammation 1.27
bar=donor   line=cohort median 		1.16 69.7%
TERT Telomere Maintenance 1.69
bar=donor   line=cohort median 		1.51 83.3%
IRS2 Insulin/IGF-1 Signaling 9.07
bar=donor   line=cohort median 		9.81 1.6%
TP53 Tumor Suppression 9.09
bar=donor   line=cohort median 		8.92 78.0%
SHC1 Signal Transduction 9.24
bar=donor   line=cohort median 		9.35 15.2%
ACE Signal Transduction 4.87
bar=donor   line=cohort median 		4.64 74.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 EEF1A1 16.9 0
2 MT-RNR2 16.9 0
3 B2M 16.7 0
4 ACTB 16.3 0
5 MT-CO1 16.2 0
6 HLA-C 15.7 0
7 TMSB4X 15.6 0
8 HLA-B 15.5 0
9 HLA-E 15.5 0
10 MT-ND4 15.4 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.6
bar=donor   line=cohort median 		14.2 14.2 19.9%
2 S100A9 14.9
bar=donor   line=cohort median 		15.4 15.5 11.6%
3 IL1B 9.0
bar=donor   line=cohort median 		9.5 9.3 36.7%
4 CXCL8 9.9
bar=donor   line=cohort median 		10.3 11.4 25.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.1
bar=donor   line=cohort median 		6.1 6.1 48.9%
6 FCGR3B 14.4
bar=donor   line=cohort median 		14.7 14.7 28.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.5
bar=donor   line=cohort median 		14.4 14.3 61.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.7
bar=donor   line=cohort median 		10.3 10.4 87.6%
9 CD3E 12.2
bar=donor   line=cohort median 		11.9 12.0 77.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		10.9 10.9 54.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.0
bar=donor   line=cohort median 		11.5 11.7 70.8%
12 GNLY 12.4
bar=donor   line=cohort median 		12.0 12.1 70.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.2
bar=donor   line=cohort median 		16.4 16.4 8.1%
17 MT-CO2 14.9
bar=donor   line=cohort median 		15.3 15.3 8.8%
18 MT-ND1 15.0
bar=donor   line=cohort median 		15.2 15.2 20.3%
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