GSM8077513

Dataset: gse255685 • Sample: YZ537 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 33.2%ile (≈ Median)
22,379 Genes with score > 0 Group median: 22,378 • 51.8%ile (≈ Median)
0 Median expression score Group median: 0 • 57.2%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

40.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.11
bar=donor   line=cohort median 		2.02 65.8%
FOXO3 Insulin/IGF-1 Signaling 9.61
bar=donor   line=cohort median 		9.99 6.3%
CETP Lipid Metabolism 5.31
bar=donor   line=cohort median 		5.05 80.8%
SIRT6 Sirtuin Family 8.26
bar=donor   line=cohort median 		8.34 31.7%
SIRT1 Sirtuin Family 8.87
bar=donor   line=cohort median 		8.72 78.0%
SIRT3 Sirtuin Family 7.42
bar=donor   line=cohort median 		7.49 36.7%
IGF1R Insulin/IGF-1 Signaling 9.74
bar=donor   line=cohort median 		10.21 13.4%
KLOTHO Anti-aging 2.41
bar=donor   line=cohort median 		2.51 34.2%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 19.5%
IL6 Inflammation 1.46
bar=donor   line=cohort median 		1.16 91.2%
TERT Telomere Maintenance 1.27
bar=donor   line=cohort median 		1.51 0.9%
IRS2 Insulin/IGF-1 Signaling 9.14
bar=donor   line=cohort median 		9.81 3.4%
TP53 Tumor Suppression 9.08
bar=donor   line=cohort median 		8.92 75.5%
SHC1 Signal Transduction 9.22
bar=donor   line=cohort median 		9.35 10.2%
ACE Signal Transduction 4.70
bar=donor   line=cohort median 		4.64 56.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.5 0
2 B2M 16.9 0
3 EEF1A1 16.6 0
4 MT-CO1 16.4 0
5 ACTB 16.2 0
6 MT-RNR1 16.1 0
7 HLA-C 16.0 0
8 MT-ND4 15.7 0
9 HLA-E 15.6 0
10 TMSB4X 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.9
bar=donor   line=cohort median 		14.2 14.2 34.2%
2 S100A9 15.1
bar=donor   line=cohort median 		15.4 15.5 20.6%
3 IL1B 9.3
bar=donor   line=cohort median 		9.5 9.3 50.0%
4 CXCL8 9.7
bar=donor   line=cohort median 		10.3 11.4 22.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.7
bar=donor   line=cohort median 		6.1 6.1 14.9%
6 FCGR3B 14.5
bar=donor   line=cohort median 		14.7 14.7 31.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 13.8
bar=donor   line=cohort median 		14.4 14.3 13.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.5
bar=donor   line=cohort median 		10.3 10.4 72.9%
9 CD3E 12.1
bar=donor   line=cohort median 		11.9 12.0 70.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.3
bar=donor   line=cohort median 		10.9 10.9 88.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.9
bar=donor   line=cohort median 		11.5 11.7 63.6%
12 GNLY 12.3
bar=donor   line=cohort median 		12.0 12.1 64.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 48.6%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.3 15.3 64.0%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.2 15.2 56.8%
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