GSM8077514

Dataset: gse255685 • Sample: YZ538 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 12.4%ile (↓ Low)
22,345 Genes with score > 0 Group median: 22,375 • 11.6%ile (↓ Low)
0 Median expression score Group median: 0 • 18.5%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

41.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.84
bar=donor   line=cohort median 		2.02 20.3%
FOXO3 Insulin/IGF-1 Signaling 9.80
bar=donor   line=cohort median 		9.99 24.6%
CETP Lipid Metabolism 5.22
bar=donor   line=cohort median 		5.05 73.7%
SIRT6 Sirtuin Family 8.13
bar=donor   line=cohort median 		8.34 8.4%
SIRT1 Sirtuin Family 8.81
bar=donor   line=cohort median 		8.72 67.9%
SIRT3 Sirtuin Family 7.25
bar=donor   line=cohort median 		7.49 10.6%
IGF1R Insulin/IGF-1 Signaling 10.08
bar=donor   line=cohort median 		10.21 37.1%
KLOTHO Anti-aging 2.27
bar=donor   line=cohort median 		2.51 14.2%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 13.4%
IL6 Inflammation 1.60
bar=donor   line=cohort median 		1.16 95.5%
TERT Telomere Maintenance 1.35
bar=donor   line=cohort median 		1.51 13.4%
IRS2 Insulin/IGF-1 Signaling 9.12
bar=donor   line=cohort median 		9.81 2.3%
TP53 Tumor Suppression 9.17
bar=donor   line=cohort median 		8.92 89.8%
SHC1 Signal Transduction 9.39
bar=donor   line=cohort median 		9.35 64.7%
ACE Signal Transduction 5.02
bar=donor   line=cohort median 		4.64 83.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.4 0
2 B2M 16.8 0
3 EEF1A1 16.7 0
4 MT-CO1 16.7 0
5 ACTB 16.4 0
6 HLA-C 16.2 0
7 MT-RNR1 16.0 0
8 MT-ND4 15.7 0
9 HLA-E 15.6 0
10 MT-CO2 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.5
bar=donor   line=cohort median 		13.8 14.2 17.4%
2 S100A9 15.1
bar=donor   line=cohort median 		15.3 15.5 19.5%
3 IL1B 9.3
bar=donor   line=cohort median 		9.5 9.3 50.7%
4 CXCL8 9.7
bar=donor   line=cohort median 		10.6 11.4 23.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.8
bar=donor   line=cohort median 		6.0 6.1 30.3%
6 FCGR3B 14.4
bar=donor   line=cohort median 		14.6 14.7 29.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 13.4
bar=donor   line=cohort median 		14.3 14.3 1.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.4
bar=donor   line=cohort median 		10.2 10.4 50.7%
9 CD3E 12.2
bar=donor   line=cohort median 		11.9 12.0 82.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.0
bar=donor   line=cohort median 		11.0 10.9 67.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.2
bar=donor   line=cohort median 		11.7 11.7 79.4%
12 GNLY 13.2
bar=donor   line=cohort median 		12.0 12.1 97.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.7
bar=donor   line=cohort median 		16.4 16.4 90.5%
17 MT-CO2 15.5
bar=donor   line=cohort median 		15.2 15.3 74.0%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.0 15.2 41.4%
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