GSM8077516

Dataset: gse255685 • Sample: YZ549 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 38.9%ile (≈ Median)
22,365 Genes with score > 0 Group median: 22,375 • 32.8%ile (≈ Median)
0 Median expression score Group median: 0 • 15.6%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

59.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.11
bar=donor   line=cohort median 		2.02 65.1%
FOXO3 Insulin/IGF-1 Signaling 10.09
bar=donor   line=cohort median 		9.99 66.5%
CETP Lipid Metabolism 4.86
bar=donor   line=cohort median 		5.05 28.5%
SIRT6 Sirtuin Family 8.32
bar=donor   line=cohort median 		8.34 44.3%
SIRT1 Sirtuin Family 8.77
bar=donor   line=cohort median 		8.72 60.4%
SIRT3 Sirtuin Family 7.42
bar=donor   line=cohort median 		7.49 37.1%
IGF1R Insulin/IGF-1 Signaling 10.53
bar=donor   line=cohort median 		10.21 84.8%
KLOTHO Anti-aging 3.06
bar=donor   line=cohort median 		2.51 97.3%
APOC3 Lipid Metabolism -2.08
bar=donor   line=cohort median 		-2.11 96.2%
IL6 Inflammation 1.09
bar=donor   line=cohort median 		1.16 32.4%
TERT Telomere Maintenance 1.54
bar=donor   line=cohort median 		1.51 55.7%
IRS2 Insulin/IGF-1 Signaling 10.25
bar=donor   line=cohort median 		9.81 75.5%
TP53 Tumor Suppression 8.92
bar=donor   line=cohort median 		8.92 50.0%
SHC1 Signal Transduction 9.49
bar=donor   line=cohort median 		9.35 84.4%
ACE Signal Transduction 4.22
bar=donor   line=cohort median 		4.64 9.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.3 0
2 B2M 16.9 0
3 ACTB 16.7 0
4 EEF1A1 16.7 0
5 MT-CO1 16.3 0
6 HLA-C 16.2 0
7 MT-RNR1 16.0 0
8 HLA-B 15.9 0
9 FTL 15.8 0
10 S100A9 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.2
bar=donor   line=cohort median 		13.8 14.2 56.8%
2 S100A9 15.7
bar=donor   line=cohort median 		15.3 15.5 66.8%
3 IL1B 10.0
bar=donor   line=cohort median 		9.5 9.3 85.8%
4 CXCL8 12.3
bar=donor   line=cohort median 		10.6 11.4 79.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 7.8
bar=donor   line=cohort median 		6.0 6.1 95.5%
6 FCGR3B 14.7
bar=donor   line=cohort median 		14.6 14.7 50.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.2
bar=donor   line=cohort median 		14.3 14.3 37.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.1
bar=donor   line=cohort median 		10.2 10.4 22.4%
9 CD3E 11.7
bar=donor   line=cohort median 		11.9 12.0 14.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.4
bar=donor   line=cohort median 		11.0 10.9 8.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.9
bar=donor   line=cohort median 		11.7 11.7 66.1%
12 GNLY 12.5
bar=donor   line=cohort median 		12.0 12.1 75.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 27.8%
17 MT-CO2 15.1
bar=donor   line=cohort median 		15.2 15.3 22.8%
18 MT-ND1 14.9
bar=donor   line=cohort median 		15.0 15.2 12.7%
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