GSM8077521

Dataset: gse255685 • Sample: YZ563 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 40.7%ile (≈ Median)
22,391 Genes with score > 0 Group median: 22,375 • 69.2%ile (≈ Median)
0 Median expression score Group median: 0 • 63.3%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

46.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.04
bar=donor   line=cohort median 		2.02 52.9%
FOXO3 Insulin/IGF-1 Signaling 9.92
bar=donor   line=cohort median 		9.99 40.3%
CETP Lipid Metabolism 5.14
bar=donor   line=cohort median 		5.05 64.0%
SIRT6 Sirtuin Family 8.31
bar=donor   line=cohort median 		8.34 41.0%
SIRT1 Sirtuin Family 8.37
bar=donor   line=cohort median 		8.72 8.8%
SIRT3 Sirtuin Family 7.64
bar=donor   line=cohort median 		7.49 76.2%
IGF1R Insulin/IGF-1 Signaling 9.97
bar=donor   line=cohort median 		10.21 29.6%
KLOTHO Anti-aging 2.53
bar=donor   line=cohort median 		2.51 53.6%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 47.9%
IL6 Inflammation 1.09
bar=donor   line=cohort median 		1.16 31.4%
TERT Telomere Maintenance 1.53
bar=donor   line=cohort median 		1.51 54.7%
IRS2 Insulin/IGF-1 Signaling 9.79
bar=donor   line=cohort median 		9.81 47.5%
TP53 Tumor Suppression 8.80
bar=donor   line=cohort median 		8.92 38.9%
SHC1 Signal Transduction 9.36
bar=donor   line=cohort median 		9.35 56.1%
ACE Signal Transduction 4.62
bar=donor   line=cohort median 		4.64 49.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 EEF1A1 17.1 0
2 MT-RNR2 16.9 0
3 B2M 16.9 0
4 MT-CO1 16.6 0
5 ACTB 16.5 0
6 HLA-B 15.9 0
7 HLA-C 15.9 0
8 HLA-E 15.7 0
9 FTL 15.7 0
10 MT-ND4 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.9
bar=donor   line=cohort median 		13.8 14.2 29.9%
2 S100A9 15.3
bar=donor   line=cohort median 		15.3 15.5 35.3%
3 IL1B 8.3
bar=donor   line=cohort median 		9.5 9.3 10.6%
4 CXCL8 11.1
bar=donor   line=cohort median 		10.6 11.4 43.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.1
bar=donor   line=cohort median 		6.0 6.1 48.6%
6 FCGR3B 14.7
bar=donor   line=cohort median 		14.6 14.7 55.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.3
bar=donor   line=cohort median 		14.3 14.3 49.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.5
bar=donor   line=cohort median 		10.2 10.4 66.5%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 45.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.3
bar=donor   line=cohort median 		11.0 10.9 84.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.1
bar=donor   line=cohort median 		11.7 11.7 7.3%
12 GNLY 11.4
bar=donor   line=cohort median 		12.0 12.1 8.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.6
bar=donor   line=cohort median 		16.4 16.4 83.3%
17 MT-CO2 15.3
bar=donor   line=cohort median 		15.2 15.3 48.6%
18 MT-ND1 15.0
bar=donor   line=cohort median 		15.0 15.2 19.9%
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