GSM8077528

Dataset: gse255685 • Sample: YZ574 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 95.9%ile (↑ High)
22,493 Genes with score > 0 Group median: 22,375 • 99.8%ile (↑ High)
0 Median expression score Group median: 0 • 98.0%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

46.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.29
bar=donor   line=cohort median 		2.02 81.2%
FOXO3 Insulin/IGF-1 Signaling 10.11
bar=donor   line=cohort median 		9.99 69.7%
CETP Lipid Metabolism 4.83
bar=donor   line=cohort median 		5.05 22.8%
SIRT6 Sirtuin Family 8.31
bar=donor   line=cohort median 		8.34 42.1%
SIRT1 Sirtuin Family 8.48
bar=donor   line=cohort median 		8.72 18.1%
SIRT3 Sirtuin Family 7.79
bar=donor   line=cohort median 		7.49 94.4%
IGF1R Insulin/IGF-1 Signaling 10.37
bar=donor   line=cohort median 		10.21 68.6%
KLOTHO Anti-aging 2.36
bar=donor   line=cohort median 		2.51 26.3%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 25.6%
IL6 Inflammation 1.07
bar=donor   line=cohort median 		1.16 23.8%
TERT Telomere Maintenance 1.35
bar=donor   line=cohort median 		1.51 14.5%
IRS2 Insulin/IGF-1 Signaling 9.97
bar=donor   line=cohort median 		9.81 62.2%
TP53 Tumor Suppression 8.70
bar=donor   line=cohort median 		8.92 27.4%
SHC1 Signal Transduction 9.36
bar=donor   line=cohort median 		9.35 52.5%
ACE Signal Transduction 4.87
bar=donor   line=cohort median 		4.64 74.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.4 0
2 EEF1A1 16.8 0
3 B2M 16.8 0
4 MT-CO1 16.4 0
5 ACTB 16.2 0
6 HLA-C 15.9 0
7 MT-RNR1 15.8 0
8 MT-ND4 15.8 0
9 HLA-E 15.5 0
10 MT-CO3 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.0
bar=donor   line=cohort median 		13.8 14.2 39.2%
2 S100A9 15.2
bar=donor   line=cohort median 		15.3 15.5 24.9%
3 IL1B 8.5
bar=donor   line=cohort median 		9.5 9.3 16.3%
4 CXCL8 10.9
bar=donor   line=cohort median 		10.6 11.4 41.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.2
bar=donor   line=cohort median 		6.0 6.1 60.8%
6 FCGR3B 14.1
bar=donor   line=cohort median 		14.6 14.7 11.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.5
bar=donor   line=cohort median 		14.3 14.3 63.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.3
bar=donor   line=cohort median 		10.2 10.4 45.0%
9 CD3E 11.8
bar=donor   line=cohort median 		11.9 12.0 22.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.4
bar=donor   line=cohort median 		11.0 10.9 94.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.0
bar=donor   line=cohort median 		11.7 11.7 3.4%
12 GNLY 11.5
bar=donor   line=cohort median 		12.0 12.1 10.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 45.7%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.2 15.3 67.2%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.0 15.2 70.1%
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