GSM8077529

Dataset: gse255685 • Sample: YZ576 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 46.8%ile (≈ Median)
22,320 Genes with score > 0 Group median: 22,378 • 1.3%ile (↓ Low)
0 Median expression score Group median: 0 • 2.7%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

61.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.73
bar=donor   line=cohort median 		2.02 4.8%
FOXO3 Insulin/IGF-1 Signaling 10.30
bar=donor   line=cohort median 		9.99 91.6%
CETP Lipid Metabolism 5.09
bar=donor   line=cohort median 		5.05 59.0%
SIRT6 Sirtuin Family 8.32
bar=donor   line=cohort median 		8.34 46.1%
SIRT1 Sirtuin Family 8.81
bar=donor   line=cohort median 		8.72 68.3%
SIRT3 Sirtuin Family 7.31
bar=donor   line=cohort median 		7.49 18.1%
IGF1R Insulin/IGF-1 Signaling 10.66
bar=donor   line=cohort median 		10.21 92.3%
KLOTHO Anti-aging 2.58
bar=donor   line=cohort median 		2.51 61.8%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 68.3%
IL6 Inflammation 1.29
bar=donor   line=cohort median 		1.16 75.1%
TERT Telomere Maintenance 1.57
bar=donor   line=cohort median 		1.51 62.2%
IRS2 Insulin/IGF-1 Signaling 9.81
bar=donor   line=cohort median 		9.81 49.3%
TP53 Tumor Suppression 9.14
bar=donor   line=cohort median 		8.92 86.9%
SHC1 Signal Transduction 9.40
bar=donor   line=cohort median 		9.35 65.8%
ACE Signal Transduction 4.81
bar=donor   line=cohort median 		4.64 67.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.6 0
2 B2M 17.2 0
3 ACTB 16.9 0
4 EEF1A1 16.7 0
5 HLA-C 16.5 0
6 MT-CO1 16.5 0
7 HLA-B 16.4 0
8 MT-RNR1 16.2 0
9 HLA-E 16.1 0
10 CSF3R 16.0 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.5
bar=donor   line=cohort median 		14.2 14.2 72.2%
2 S100A9 16.0
bar=donor   line=cohort median 		15.4 15.5 81.9%
3 IL1B 10.4
bar=donor   line=cohort median 		9.5 9.3 96.2%
4 CXCL8 9.3
bar=donor   line=cohort median 		10.3 11.4 15.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.5
bar=donor   line=cohort median 		6.1 6.1 75.1%
6 FCGR3B 15.4
bar=donor   line=cohort median 		14.7 14.7 94.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.8
bar=donor   line=cohort median 		14.4 14.3 83.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.2
bar=donor   line=cohort median 		10.3 10.4 24.6%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 50.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.6
bar=donor   line=cohort median 		10.9 10.9 22.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.5
bar=donor   line=cohort median 		11.5 11.7 36.4%
12 GNLY 11.7
bar=donor   line=cohort median 		12.0 12.1 19.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 62.5%
17 MT-CO2 15.3
bar=donor   line=cohort median 		15.3 15.3 50.0%
18 MT-ND1 15.4
bar=donor   line=cohort median 		15.2 15.2 76.9%
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