GSM8077530

Dataset: gse255685 • Sample: YZ580 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 82.6%ile (↑ High)
22,427 Genes with score > 0 Group median: 22,378 • 92.8%ile (↑ High)
0 Median expression score Group median: 0 • 84.8%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

44.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.79
bar=donor   line=cohort median 		2.02 12.7%
FOXO3 Insulin/IGF-1 Signaling 9.98
bar=donor   line=cohort median 		9.99 46.8%
CETP Lipid Metabolism 4.70
bar=donor   line=cohort median 		5.05 13.4%
SIRT6 Sirtuin Family 8.16
bar=donor   line=cohort median 		8.34 13.4%
SIRT1 Sirtuin Family 8.55
bar=donor   line=cohort median 		8.72 26.3%
SIRT3 Sirtuin Family 7.61
bar=donor   line=cohort median 		7.49 72.2%
IGF1R Insulin/IGF-1 Signaling 10.34
bar=donor   line=cohort median 		10.21 64.0%
KLOTHO Anti-aging 2.38
bar=donor   line=cohort median 		2.51 31.7%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 39.6%
IL6 Inflammation 1.32
bar=donor   line=cohort median 		1.16 79.0%
TERT Telomere Maintenance 1.45
bar=donor   line=cohort median 		1.51 36.0%
IRS2 Insulin/IGF-1 Signaling 10.65
bar=donor   line=cohort median 		9.81 88.7%
TP53 Tumor Suppression 8.70
bar=donor   line=cohort median 		8.92 27.1%
SHC1 Signal Transduction 9.26
bar=donor   line=cohort median 		9.35 19.2%
ACE Signal Transduction 5.13
bar=donor   line=cohort median 		4.64 91.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.1 0
2 EEF1A1 17.0 0
3 B2M 16.6 0
4 MT-CO1 16.5 0
5 ACTB 16.4 0
6 HLA-C 15.8 0
7 FKBP8 15.8 0
8 MT-ND4 15.8 0
9 TXNIP 15.7 0
10 MT-RNR1 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.4
bar=donor   line=cohort median 		14.2 14.2 12.7%
2 S100A9 14.8
bar=donor   line=cohort median 		15.4 15.5 8.1%
3 IL1B 7.8
bar=donor   line=cohort median 		9.5 9.3 3.0%
4 CXCL8 11.8
bar=donor   line=cohort median 		10.3 11.4 62.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.7
bar=donor   line=cohort median 		6.1 6.1 17.4%
6 FCGR3B 14.0
bar=donor   line=cohort median 		14.7 14.7 8.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.0
bar=donor   line=cohort median 		14.4 14.3 19.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.4
bar=donor   line=cohort median 		10.3 10.4 60.4%
9 CD3E 12.1
bar=donor   line=cohort median 		11.9 12.0 72.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.3
bar=donor   line=cohort median 		10.9 10.9 91.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.2
bar=donor   line=cohort median 		11.5 11.7 10.9%
12 GNLY 11.4
bar=donor   line=cohort median 		12.0 12.1 7.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 72.2%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.3 15.3 62.2%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.2 15.2 42.1%
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