GSM8077531

Dataset: gse255685 • Sample: YZ581 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 65.4%ile (≈ Median)
22,443 Genes with score > 0 Group median: 22,378 • 96.2%ile (↑ High)
0 Median expression score Group median: 0 • 96.2%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

44.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.06
bar=donor   line=cohort median 		2.02 57.9%
FOXO3 Insulin/IGF-1 Signaling 9.77
bar=donor   line=cohort median 		9.99 22.4%
CETP Lipid Metabolism 4.76
bar=donor   line=cohort median 		5.05 16.7%
SIRT6 Sirtuin Family 8.11
bar=donor   line=cohort median 		8.34 6.6%
SIRT1 Sirtuin Family 8.53
bar=donor   line=cohort median 		8.72 22.8%
SIRT3 Sirtuin Family 7.81
bar=donor   line=cohort median 		7.49 95.5%
IGF1R Insulin/IGF-1 Signaling 10.19
bar=donor   line=cohort median 		10.21 48.2%
KLOTHO Anti-aging 2.41
bar=donor   line=cohort median 		2.51 36.0%
APOC3 Lipid Metabolism -2.12
bar=donor   line=cohort median 		-2.11 1.3%
IL6 Inflammation 1.32
bar=donor   line=cohort median 		1.16 80.1%
TERT Telomere Maintenance 1.64
bar=donor   line=cohort median 		1.51 77.6%
IRS2 Insulin/IGF-1 Signaling 9.78
bar=donor   line=cohort median 		9.81 46.1%
TP53 Tumor Suppression 8.67
bar=donor   line=cohort median 		8.92 23.5%
SHC1 Signal Transduction 9.32
bar=donor   line=cohort median 		9.35 39.3%
ACE Signal Transduction 5.11
bar=donor   line=cohort median 		4.64 91.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.2 0
2 EEF1A1 16.9 0
3 B2M 16.4 0
4 MT-CO1 16.3 0
5 ACTB 16.1 0
6 MT-RNR1 15.8 0
7 MT-ND4 15.8 0
8 HLA-C 15.5 0
9 HLA-E 15.4 0
10 MT-CO3 15.4 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.9
bar=donor   line=cohort median 		14.2 14.2 8.8%
2 S100A9 14.3
bar=donor   line=cohort median 		15.4 15.5 1.3%
3 IL1B 7.5
bar=donor   line=cohort median 		9.5 9.3 0.9%
4 CXCL8 10.1
bar=donor   line=cohort median 		10.3 11.4 28.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.5
bar=donor   line=cohort median 		6.1 6.1 4.8%
6 FCGR3B 13.8
bar=donor   line=cohort median 		14.7 14.7 4.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 13.9
bar=donor   line=cohort median 		14.4 14.3 13.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.4
bar=donor   line=cohort median 		10.3 10.4 56.8%
9 CD3E 12.1
bar=donor   line=cohort median 		11.9 12.0 68.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.4
bar=donor   line=cohort median 		10.9 10.9 93.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.3
bar=donor   line=cohort median 		11.5 11.7 19.9%
12 GNLY 11.4
bar=donor   line=cohort median 		12.0 12.1 5.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 29.6%
17 MT-CO2 15.2
bar=donor   line=cohort median 		15.3 15.3 34.2%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.2 15.2 52.2%
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