GSM8077533

Dataset: gse255685 • Sample: YZ588 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 65.1%ile (≈ Median)
22,391 Genes with score > 0 Group median: 22,378 • 69.2%ile (≈ Median)
0 Median expression score Group median: 0 • 55.7%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

54.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.86
bar=donor   line=cohort median 		2.02 22.8%
FOXO3 Insulin/IGF-1 Signaling 10.02
bar=donor   line=cohort median 		9.99 53.9%
CETP Lipid Metabolism 5.45
bar=donor   line=cohort median 		5.05 89.4%
SIRT6 Sirtuin Family 8.15
bar=donor   line=cohort median 		8.34 10.6%
SIRT1 Sirtuin Family 8.75
bar=donor   line=cohort median 		8.72 56.5%
SIRT3 Sirtuin Family 7.51
bar=donor   line=cohort median 		7.49 53.6%
IGF1R Insulin/IGF-1 Signaling 10.51
bar=donor   line=cohort median 		10.21 83.0%
KLOTHO Anti-aging 2.91
bar=donor   line=cohort median 		2.51 92.3%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 28.1%
IL6 Inflammation 1.59
bar=donor   line=cohort median 		1.16 95.2%
TERT Telomere Maintenance 1.43
bar=donor   line=cohort median 		1.51 32.8%
IRS2 Insulin/IGF-1 Signaling 9.73
bar=donor   line=cohort median 		9.81 42.5%
TP53 Tumor Suppression 9.01
bar=donor   line=cohort median 		8.92 63.6%
SHC1 Signal Transduction 9.34
bar=donor   line=cohort median 		9.35 44.6%
ACE Signal Transduction 4.64
bar=donor   line=cohort median 		4.64 49.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.6 0
2 B2M 16.9 0
3 ACTB 16.4 0
4 EEF1A1 16.4 0
5 MT-CO1 16.3 0
6 HLA-C 16.1 0
7 MT-RNR1 16.0 0
8 HLA-E 15.7 0
9 MT-ND4 15.6 0
10 HLA-B 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.6
bar=donor   line=cohort median 		14.2 14.2 19.2%
2 S100A9 15.1
bar=donor   line=cohort median 		15.4 15.5 19.9%
3 IL1B 9.7
bar=donor   line=cohort median 		9.5 9.3 69.7%
4 CXCL8 9.3
bar=donor   line=cohort median 		10.3 11.4 15.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 7.8
bar=donor   line=cohort median 		6.1 6.1 95.9%
6 FCGR3B 14.7
bar=donor   line=cohort median 		14.7 14.7 51.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.5
bar=donor   line=cohort median 		14.4 14.3 59.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.9
bar=donor   line=cohort median 		10.3 10.4 9.5%
9 CD3E 11.5
bar=donor   line=cohort median 		11.9 12.0 2.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		10.9 10.9 55.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.1
bar=donor   line=cohort median 		11.5 11.7 74.4%
12 GNLY 13.2
bar=donor   line=cohort median 		12.0 12.1 97.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 32.4%
17 MT-CO2 15.1
bar=donor   line=cohort median 		15.3 15.3 17.4%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.2 15.2 50.4%
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