GSM8077535

Dataset: gse255685 • Sample: YZ592 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 74.7%ile (≈ Median)
22,408 Genes with score > 0 Group median: 22,378 • 81.9%ile (↑ High)
0 Median expression score Group median: 0 • 84.1%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

48.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.33
bar=donor   line=cohort median 		2.02 84.8%
FOXO3 Insulin/IGF-1 Signaling 10.07
bar=donor   line=cohort median 		9.99 61.5%
CETP Lipid Metabolism 4.82
bar=donor   line=cohort median 		5.05 21.0%
SIRT6 Sirtuin Family 8.23
bar=donor   line=cohort median 		8.34 23.8%
SIRT1 Sirtuin Family 8.61
bar=donor   line=cohort median 		8.72 36.7%
SIRT3 Sirtuin Family 7.55
bar=donor   line=cohort median 		7.49 61.5%
IGF1R Insulin/IGF-1 Signaling 9.96
bar=donor   line=cohort median 		10.21 27.8%
KLOTHO Anti-aging 2.19
bar=donor   line=cohort median 		2.51 8.1%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 62.9%
IL6 Inflammation 1.10
bar=donor   line=cohort median 		1.16 35.0%
TERT Telomere Maintenance 1.71
bar=donor   line=cohort median 		1.51 84.4%
IRS2 Insulin/IGF-1 Signaling 9.80
bar=donor   line=cohort median 		9.81 48.2%
TP53 Tumor Suppression 8.89
bar=donor   line=cohort median 		8.92 48.6%
SHC1 Signal Transduction 9.30
bar=donor   line=cohort median 		9.35 35.0%
ACE Signal Transduction 5.09
bar=donor   line=cohort median 		4.64 90.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.6 0
2 EEF1A1 17.0 0
3 B2M 16.9 0
4 MT-CO1 16.8 0
5 ACTB 16.5 0
6 HLA-C 16.1 0
7 MT-RNR1 16.1 0
8 MT-ND4 15.9 0
9 FTL 15.8 0
10 HLA-E 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.8
bar=donor   line=cohort median 		14.2 14.2 27.8%
2 S100A9 15.2
bar=donor   line=cohort median 		15.4 15.5 27.1%
3 IL1B 8.0
bar=donor   line=cohort median 		9.5 9.3 4.1%
4 CXCL8 11.8
bar=donor   line=cohort median 		10.3 11.4 61.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.7
bar=donor   line=cohort median 		6.1 6.1 18.1%
6 FCGR3B 14.2
bar=donor   line=cohort median 		14.7 14.7 13.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.2
bar=donor   line=cohort median 		14.4 14.3 36.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.5
bar=donor   line=cohort median 		10.3 10.4 68.6%
9 CD3E 12.3
bar=donor   line=cohort median 		11.9 12.0 88.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.2
bar=donor   line=cohort median 		10.9 10.9 79.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.4
bar=donor   line=cohort median 		11.5 11.7 27.1%
12 GNLY 11.8
bar=donor   line=cohort median 		12.0 12.1 23.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.8
bar=donor   line=cohort median 		16.4 16.4 94.8%
17 MT-CO2 15.5
bar=donor   line=cohort median 		15.3 15.3 78.7%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.2 15.2 71.5%
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