GSM8077536

Dataset: gse255685 • Sample: YZ593 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 79.7%ile (↑ High)
22,401 Genes with score > 0 Group median: 22,378 • 74.4%ile (≈ Median)
0 Median expression score Group median: 0 • 73.3%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

53.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.11
bar=donor   line=cohort median 		2.02 65.4%
FOXO3 Insulin/IGF-1 Signaling 10.29
bar=donor   line=cohort median 		9.99 89.4%
CETP Lipid Metabolism 4.87
bar=donor   line=cohort median 		5.05 30.7%
SIRT6 Sirtuin Family 8.35
bar=donor   line=cohort median 		8.34 53.6%
SIRT1 Sirtuin Family 8.53
bar=donor   line=cohort median 		8.72 22.4%
SIRT3 Sirtuin Family 7.57
bar=donor   line=cohort median 		7.49 64.7%
IGF1R Insulin/IGF-1 Signaling 10.59
bar=donor   line=cohort median 		10.21 88.7%
KLOTHO Anti-aging 2.35
bar=donor   line=cohort median 		2.51 26.0%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 19.2%
IL6 Inflammation 1.07
bar=donor   line=cohort median 		1.16 22.4%
TERT Telomere Maintenance 1.43
bar=donor   line=cohort median 		1.51 29.6%
IRS2 Insulin/IGF-1 Signaling 10.67
bar=donor   line=cohort median 		9.81 90.1%
TP53 Tumor Suppression 8.76
bar=donor   line=cohort median 		8.92 33.5%
SHC1 Signal Transduction 9.52
bar=donor   line=cohort median 		9.35 89.4%
ACE Signal Transduction 4.99
bar=donor   line=cohort median 		4.64 82.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MTCO2P12 26.8 0
2 MT-RNR2 17.0 0
3 B2M 16.8 0
4 EEF1A1 16.8 0
5 ACTB 16.6 0
6 MT-CO1 16.4 0
7 HLA-C 16.1 0
8 HLA-B 15.8 0
9 FTL 15.8 0
10 CSF3R 15.8 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.0
bar=donor   line=cohort median 		14.2 14.2 39.6%
2 S100A9 15.6
bar=donor   line=cohort median 		15.4 15.5 52.9%
3 IL1B 9.5
bar=donor   line=cohort median 		9.5 9.3 62.2%
4 CXCL8 12.3
bar=donor   line=cohort median 		10.3 11.4 80.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.6
bar=donor   line=cohort median 		6.1 6.1 78.3%
6 FCGR3B 14.5
bar=donor   line=cohort median 		14.7 14.7 29.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.7
bar=donor   line=cohort median 		14.4 14.3 78.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.9
bar=donor   line=cohort median 		10.3 10.4 9.9%
9 CD3E 11.7
bar=donor   line=cohort median 		11.9 12.0 8.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.6
bar=donor   line=cohort median 		10.9 10.9 23.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.3
bar=donor   line=cohort median 		11.5 11.7 16.3%
12 GNLY 11.4
bar=donor   line=cohort median 		12.0 12.1 4.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 55.0%
17 MT-CO2 15.3
bar=donor   line=cohort median 		15.3 15.3 46.8%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.2 15.2 43.5%
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