GSM8077539

Dataset: gse255685 • Sample: YZ605 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 74.4%ile (≈ Median)
22,390 Genes with score > 0 Group median: 22,378 • 67.7%ile (≈ Median)
0 Median expression score Group median: 0 • 58.2%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

64.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.92
bar=donor   line=cohort median 		2.02 35.0%
FOXO3 Insulin/IGF-1 Signaling 10.28
bar=donor   line=cohort median 		9.99 88.7%
CETP Lipid Metabolism 5.23
bar=donor   line=cohort median 		5.05 74.7%
SIRT6 Sirtuin Family 8.37
bar=donor   line=cohort median 		8.34 59.0%
SIRT1 Sirtuin Family 8.88
bar=donor   line=cohort median 		8.72 80.8%
SIRT3 Sirtuin Family 7.68
bar=donor   line=cohort median 		7.49 82.6%
IGF1R Insulin/IGF-1 Signaling 10.70
bar=donor   line=cohort median 		10.21 95.2%
KLOTHO Anti-aging 2.78
bar=donor   line=cohort median 		2.51 85.1%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 70.8%
IL6 Inflammation 1.21
bar=donor   line=cohort median 		1.16 60.0%
TERT Telomere Maintenance 1.57
bar=donor   line=cohort median 		1.51 63.3%
IRS2 Insulin/IGF-1 Signaling 9.86
bar=donor   line=cohort median 		9.81 53.6%
TP53 Tumor Suppression 9.03
bar=donor   line=cohort median 		8.92 69.7%
SHC1 Signal Transduction 9.23
bar=donor   line=cohort median 		9.35 12.4%
ACE Signal Transduction 4.56
bar=donor   line=cohort median 		4.64 42.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.6 0
2 B2M 17.0 0
3 ACTB 16.8 0
4 EEF1A1 16.5 0
5 HLA-C 16.4 0
6 MT-CO1 16.3 0
7 HLA-B 16.1 0
8 MT-RNR1 16.0 0
9 FTL 16.0 0
10 CSF3R 16.0 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.5
bar=donor   line=cohort median 		14.2 14.2 73.3%
2 S100A9 15.9
bar=donor   line=cohort median 		15.4 15.5 74.4%
3 IL1B 9.9
bar=donor   line=cohort median 		9.5 9.3 83.0%
4 CXCL8 9.6
bar=donor   line=cohort median 		10.3 11.4 19.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.2
bar=donor   line=cohort median 		6.1 6.1 61.5%
6 FCGR3B 14.5
bar=donor   line=cohort median 		14.7 14.7 37.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.0
bar=donor   line=cohort median 		14.4 14.3 19.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.1
bar=donor   line=cohort median 		10.3 10.4 21.0%
9 CD3E 11.8
bar=donor   line=cohort median 		11.9 12.0 22.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.8
bar=donor   line=cohort median 		10.9 10.9 34.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.3
bar=donor   line=cohort median 		11.5 11.7 13.4%
12 GNLY 11.2
bar=donor   line=cohort median 		12.0 12.1 1.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 28.1%
17 MT-CO2 15.3
bar=donor   line=cohort median 		15.3 15.3 41.0%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.2 15.2 51.8%
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