GSM8077540

Dataset: gse255685 • Sample: YZ607 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 36.7%ile (≈ Median)
22,391 Genes with score > 0 Group median: 22,375 • 69.2%ile (≈ Median)
0 Median expression score Group median: 0 • 55.0%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

56.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.90
bar=donor   line=cohort median 		2.02 32.1%
FOXO3 Insulin/IGF-1 Signaling 10.18
bar=donor   line=cohort median 		9.99 80.5%
CETP Lipid Metabolism 5.16
bar=donor   line=cohort median 		5.05 66.1%
SIRT6 Sirtuin Family 8.12
bar=donor   line=cohort median 		8.34 8.1%
SIRT1 Sirtuin Family 8.93
bar=donor   line=cohort median 		8.72 89.4%
SIRT3 Sirtuin Family 7.33
bar=donor   line=cohort median 		7.49 21.7%
IGF1R Insulin/IGF-1 Signaling 10.71
bar=donor   line=cohort median 		10.21 95.9%
KLOTHO Anti-aging 2.87
bar=donor   line=cohort median 		2.51 89.8%
APOC3 Lipid Metabolism -2.12
bar=donor   line=cohort median 		-2.11 0.5%
IL6 Inflammation 1.26
bar=donor   line=cohort median 		1.16 69.0%
TERT Telomere Maintenance 1.37
bar=donor   line=cohort median 		1.51 18.8%
IRS2 Insulin/IGF-1 Signaling 10.02
bar=donor   line=cohort median 		9.81 66.1%
TP53 Tumor Suppression 9.05
bar=donor   line=cohort median 		8.92 72.6%
SHC1 Signal Transduction 9.48
bar=donor   line=cohort median 		9.35 83.0%
ACE Signal Transduction 4.74
bar=donor   line=cohort median 		4.64 60.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.4 0
2 B2M 16.8 0
3 EEF1A1 16.7 0
4 MT-CO1 16.5 0
5 ACTB 16.4 0
6 MT-RNR1 16.0 0
7 HLA-B 15.7 0
8 TXNIP 15.7 0
9 HLA-E 15.6 0
10 CSF3R 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.8
bar=donor   line=cohort median 		13.8 14.2 29.2%
2 S100A9 15.4
bar=donor   line=cohort median 		15.3 15.5 36.7%
3 IL1B 9.2
bar=donor   line=cohort median 		9.5 9.3 43.2%
4 CXCL8 8.6
bar=donor   line=cohort median 		10.6 11.4 6.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.8
bar=donor   line=cohort median 		6.0 6.1 82.3%
6 FCGR3B 14.6
bar=donor   line=cohort median 		14.6 14.7 37.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.5
bar=donor   line=cohort median 		14.3 14.3 59.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.1
bar=donor   line=cohort median 		10.2 10.4 16.3%
9 CD3E 11.8
bar=donor   line=cohort median 		11.9 12.0 24.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.4
bar=donor   line=cohort median 		11.0 10.9 7.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.7
bar=donor   line=cohort median 		11.7 11.7 47.5%
12 GNLY 12.4
bar=donor   line=cohort median 		12.0 12.1 68.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 61.5%
17 MT-CO2 15.2
bar=donor   line=cohort median 		15.2 15.3 29.6%
18 MT-ND1 14.9
bar=donor   line=cohort median 		15.0 15.2 15.2%
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