GSM8077545

Dataset: gse255685 • Sample: YZ614 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 69.4%ile (≈ Median)
22,392 Genes with score > 0 Group median: 22,378 • 70.3%ile (≈ Median)
0 Median expression score Group median: 0 • 69.7%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

49.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.21
bar=donor   line=cohort median 		2.02 76.9%
FOXO3 Insulin/IGF-1 Signaling 10.19
bar=donor   line=cohort median 		9.99 82.3%
CETP Lipid Metabolism 5.30
bar=donor   line=cohort median 		5.05 79.4%
SIRT6 Sirtuin Family 8.24
bar=donor   line=cohort median 		8.34 27.4%
SIRT1 Sirtuin Family 8.75
bar=donor   line=cohort median 		8.72 54.7%
SIRT3 Sirtuin Family 7.44
bar=donor   line=cohort median 		7.49 40.3%
IGF1R Insulin/IGF-1 Signaling 10.30
bar=donor   line=cohort median 		10.21 58.2%
KLOTHO Anti-aging 2.34
bar=donor   line=cohort median 		2.51 25.3%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 16.3%
IL6 Inflammation 1.14
bar=donor   line=cohort median 		1.16 45.0%
TERT Telomere Maintenance 1.68
bar=donor   line=cohort median 		1.51 81.9%
IRS2 Insulin/IGF-1 Signaling 9.99
bar=donor   line=cohort median 		9.81 63.6%
TP53 Tumor Suppression 8.76
bar=donor   line=cohort median 		8.92 33.9%
SHC1 Signal Transduction 9.30
bar=donor   line=cohort median 		9.35 33.9%
ACE Signal Transduction 4.31
bar=donor   line=cohort median 		4.64 17.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.6 0
2 B2M 17.1 0
3 EEF1A1 16.5 0
4 ACTB 16.5 0
5 MT-CO1 16.3 0
6 HLA-C 16.3 0
7 MT-RNR1 16.2 0
8 HLA-E 15.9 0
9 S100A9 15.9 0
10 CSF3R 15.8 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.9
bar=donor   line=cohort median 		14.2 14.2 88.7%
2 S100A9 15.9
bar=donor   line=cohort median 		15.4 15.5 76.2%
3 IL1B 9.8
bar=donor   line=cohort median 		9.5 9.3 76.9%
4 CXCL8 9.7
bar=donor   line=cohort median 		10.3 11.4 21.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.6
bar=donor   line=cohort median 		6.1 6.1 13.1%
6 FCGR3B 15.4
bar=donor   line=cohort median 		14.7 14.7 93.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.4
bar=donor   line=cohort median 		14.4 14.3 52.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.2
bar=donor   line=cohort median 		10.3 10.4 27.1%
9 CD3E 11.8
bar=donor   line=cohort median 		11.9 12.0 16.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.8
bar=donor   line=cohort median 		10.9 10.9 34.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.3
bar=donor   line=cohort median 		11.5 11.7 14.5%
12 GNLY 12.0
bar=donor   line=cohort median 		12.0 12.1 40.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 22.4%
17 MT-CO2 15.3
bar=donor   line=cohort median 		15.3 15.3 39.6%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.2 15.2 63.6%
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