GSM8077546

Dataset: gse255685 • Sample: YZ616 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 47.5%ile (≈ Median)
22,375 Genes with score > 0 Group median: 22,375 • 45.0%ile (≈ Median)
0 Median expression score Group median: 0 • 72.9%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

58.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.91
bar=donor   line=cohort median 		2.02 33.2%
FOXO3 Insulin/IGF-1 Signaling 10.00
bar=donor   line=cohort median 		9.99 51.1%
CETP Lipid Metabolism 5.09
bar=donor   line=cohort median 		5.05 58.2%
SIRT6 Sirtuin Family 8.20
bar=donor   line=cohort median 		8.34 19.5%
SIRT1 Sirtuin Family 9.05
bar=donor   line=cohort median 		8.72 97.3%
SIRT3 Sirtuin Family 7.38
bar=donor   line=cohort median 		7.49 31.4%
IGF1R Insulin/IGF-1 Signaling 10.67
bar=donor   line=cohort median 		10.21 93.0%
KLOTHO Anti-aging 3.06
bar=donor   line=cohort median 		2.51 97.7%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 12.0%
IL6 Inflammation 1.06
bar=donor   line=cohort median 		1.16 21.3%
TERT Telomere Maintenance 1.67
bar=donor   line=cohort median 		1.51 79.8%
IRS2 Insulin/IGF-1 Signaling 9.88
bar=donor   line=cohort median 		9.81 55.4%
TP53 Tumor Suppression 9.10
bar=donor   line=cohort median 		8.92 79.4%
SHC1 Signal Transduction 9.42
bar=donor   line=cohort median 		9.35 70.8%
ACE Signal Transduction 4.98
bar=donor   line=cohort median 		4.64 81.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.5 0
2 EEF1A1 16.7 0
3 B2M 16.6 0
4 MT-CO1 16.4 0
5 ACTB 16.3 0
6 MT-RNR1 16.2 0
7 MT-ND4 15.6 0
8 HLA-B 15.5 0
9 HLA-E 15.5 0
10 FTL 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.3
bar=donor   line=cohort median 		13.8 14.2 11.6%
2 S100A9 14.9
bar=donor   line=cohort median 		15.3 15.5 9.1%
3 IL1B 9.1
bar=donor   line=cohort median 		9.5 9.3 40.0%
4 CXCL8 10.7
bar=donor   line=cohort median 		10.6 11.4 38.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.5
bar=donor   line=cohort median 		6.0 6.1 7.7%
6 FCGR3B 14.3
bar=donor   line=cohort median 		14.6 14.7 19.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.3
bar=donor   line=cohort median 		14.3 14.3 48.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.2
bar=donor   line=cohort median 		10.2 10.4 35.7%
9 CD3E 11.8
bar=donor   line=cohort median 		11.9 12.0 19.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.1
bar=donor   line=cohort median 		11.0 10.9 72.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.3
bar=donor   line=cohort median 		11.7 11.7 15.9%
12 GNLY 11.8
bar=donor   line=cohort median 		12.0 12.1 28.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 52.2%
17 MT-CO2 15.1
bar=donor   line=cohort median 		15.2 15.3 23.8%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.0 15.2 42.5%
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