GSM8077547

Dataset: gse255685 • Sample: YZ618 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 45.7%ile (≈ Median)
22,355 Genes with score > 0 Group median: 22,378 • 19.7%ile (↓ Low)
0 Median expression score Group median: 0 • 13.4%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

42.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.04
bar=donor   line=cohort median 		2.02 53.9%
FOXO3 Insulin/IGF-1 Signaling 9.91
bar=donor   line=cohort median 		9.99 38.9%
CETP Lipid Metabolism 5.24
bar=donor   line=cohort median 		5.05 75.1%
SIRT6 Sirtuin Family 8.27
bar=donor   line=cohort median 		8.34 33.5%
SIRT1 Sirtuin Family 8.68
bar=donor   line=cohort median 		8.72 45.7%
SIRT3 Sirtuin Family 7.06
bar=donor   line=cohort median 		7.49 3.1%
IGF1R Insulin/IGF-1 Signaling 10.12
bar=donor   line=cohort median 		10.21 41.8%
KLOTHO Anti-aging 2.57
bar=donor   line=cohort median 		2.51 59.7%
APOC3 Lipid Metabolism -2.10
bar=donor   line=cohort median 		-2.11 80.8%
IL6 Inflammation 1.41
bar=donor   line=cohort median 		1.16 86.6%
TERT Telomere Maintenance 1.31
bar=donor   line=cohort median 		1.51 8.4%
IRS2 Insulin/IGF-1 Signaling 9.54
bar=donor   line=cohort median 		9.81 25.6%
TP53 Tumor Suppression 8.96
bar=donor   line=cohort median 		8.92 57.2%
SHC1 Signal Transduction 9.29
bar=donor   line=cohort median 		9.35 28.1%
ACE Signal Transduction 4.09
bar=donor   line=cohort median 		4.64 3.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.7 0
2 B2M 17.2 0
3 ACTB 16.6 0
4 EEF1A1 16.6 0
5 HLA-C 16.4 0
6 MT-CO1 16.2 0
7 MT-RNR1 16.2 0
8 HLA-B 16.1 0
9 FTL 16.0 0
10 HLA-E 15.9 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.8
bar=donor   line=cohort median 		14.2 14.2 87.3%
2 S100A9 15.9
bar=donor   line=cohort median 		15.4 15.5 76.5%
3 IL1B 10.1
bar=donor   line=cohort median 		9.5 9.3 90.1%
4 CXCL8 10.0
bar=donor   line=cohort median 		10.3 11.4 28.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.6
bar=donor   line=cohort median 		6.1 6.1 11.3%
6 FCGR3B 15.3
bar=donor   line=cohort median 		14.7 14.7 90.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.2
bar=donor   line=cohort median 		14.4 14.3 34.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.4
bar=donor   line=cohort median 		10.3 10.4 56.1%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 42.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.1
bar=donor   line=cohort median 		10.9 10.9 71.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.9
bar=donor   line=cohort median 		11.5 11.7 64.3%
12 GNLY 12.5
bar=donor   line=cohort median 		12.0 12.1 76.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.2
bar=donor   line=cohort median 		16.4 16.4 13.8%
17 MT-CO2 15.1
bar=donor   line=cohort median 		15.3 15.3 20.6%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.2 15.2 64.7%
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