GSM8077548

Dataset: gse255685 • Sample: YZ619 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 33.9%ile (≈ Median)
22,351 Genes with score > 0 Group median: 22,375 • 15.4%ile (↓ Low)
0 Median expression score Group median: 0 • 6.3%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

54.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.83
bar=donor   line=cohort median 		2.02 18.8%
FOXO3 Insulin/IGF-1 Signaling 10.03
bar=donor   line=cohort median 		9.99 55.4%
CETP Lipid Metabolism 4.96
bar=donor   line=cohort median 		5.05 40.3%
SIRT6 Sirtuin Family 8.23
bar=donor   line=cohort median 		8.34 24.6%
SIRT1 Sirtuin Family 8.87
bar=donor   line=cohort median 		8.72 78.3%
SIRT3 Sirtuin Family 7.65
bar=donor   line=cohort median 		7.49 78.3%
IGF1R Insulin/IGF-1 Signaling 10.12
bar=donor   line=cohort median 		10.21 41.0%
KLOTHO Anti-aging 2.89
bar=donor   line=cohort median 		2.51 90.5%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 72.2%
IL6 Inflammation 1.11
bar=donor   line=cohort median 		1.16 37.1%
TERT Telomere Maintenance 1.58
bar=donor   line=cohort median 		1.51 64.7%
IRS2 Insulin/IGF-1 Signaling 9.47
bar=donor   line=cohort median 		9.81 21.0%
TP53 Tumor Suppression 9.08
bar=donor   line=cohort median 		8.92 76.5%
SHC1 Signal Transduction 9.33
bar=donor   line=cohort median 		9.35 43.2%
ACE Signal Transduction 4.85
bar=donor   line=cohort median 		4.64 72.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.4 0
2 B2M 17.0 0
3 EEF1A1 16.7 0
4 ACTB 16.6 0
5 MT-CO1 16.4 0
6 HLA-B 16.3 0
7 MT-RNR1 15.9 0
8 FTL 15.9 0
9 HLA-E 15.7 0
10 S100A9 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.1
bar=donor   line=cohort median 		13.8 14.2 47.5%
2 S100A9 15.6
bar=donor   line=cohort median 		15.3 15.5 57.2%
3 IL1B 9.7
bar=donor   line=cohort median 		9.5 9.3 72.6%
4 CXCL8 9.5
bar=donor   line=cohort median 		10.6 11.4 18.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 7.8
bar=donor   line=cohort median 		6.0 6.1 95.2%
6 FCGR3B 14.8
bar=donor   line=cohort median 		14.6 14.7 59.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.5
bar=donor   line=cohort median 		14.3 14.3 64.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.3
bar=donor   line=cohort median 		10.2 10.4 40.0%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 37.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		11.0 10.9 55.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.7
bar=donor   line=cohort median 		11.7 11.7 46.8%
12 GNLY 12.3
bar=donor   line=cohort median 		12.0 12.1 66.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 40.7%
17 MT-CO2 15.2
bar=donor   line=cohort median 		15.2 15.3 33.9%
18 MT-ND1 15.0
bar=donor   line=cohort median 		15.0 15.2 18.5%
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