GSM8077550

Dataset: gse255685 • Sample: YZ622 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 93.0%ile (↑ High)
22,410 Genes with score > 0 Group median: 22,378 • 84.1%ile (↑ High)
0 Median expression score Group median: 0 • 91.6%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

58.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.09
bar=donor   line=cohort median 		2.02 61.1%
FOXO3 Insulin/IGF-1 Signaling 9.90
bar=donor   line=cohort median 		9.99 36.4%
CETP Lipid Metabolism 5.13
bar=donor   line=cohort median 		5.05 62.9%
SIRT6 Sirtuin Family 8.15
bar=donor   line=cohort median 		8.34 11.3%
SIRT1 Sirtuin Family 8.86
bar=donor   line=cohort median 		8.72 75.5%
SIRT3 Sirtuin Family 7.57
bar=donor   line=cohort median 		7.49 63.3%
IGF1R Insulin/IGF-1 Signaling 10.44
bar=donor   line=cohort median 		10.21 75.8%
KLOTHO Anti-aging 2.59
bar=donor   line=cohort median 		2.51 63.6%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 69.7%
IL6 Inflammation 1.20
bar=donor   line=cohort median 		1.16 59.7%
TERT Telomere Maintenance 1.40
bar=donor   line=cohort median 		1.51 24.2%
IRS2 Insulin/IGF-1 Signaling 10.19
bar=donor   line=cohort median 		9.81 71.9%
TP53 Tumor Suppression 8.87
bar=donor   line=cohort median 		8.92 47.1%
SHC1 Signal Transduction 9.48
bar=donor   line=cohort median 		9.35 83.3%
ACE Signal Transduction 4.77
bar=donor   line=cohort median 		4.64 64.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.4 0
2 EEF1A1 16.6 0
3 B2M 16.6 0
4 MT-CO1 16.3 0
5 ACTB 16.1 0
6 MT-RNR1 15.7 0
7 MT-ND4 15.7 0
8 FTL 15.5 0
9 TMSB4X 15.4 0
10 HLA-B 15.4 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.9
bar=donor   line=cohort median 		14.2 14.2 36.4%
2 S100A9 15.0
bar=donor   line=cohort median 		15.4 15.5 14.2%
3 IL1B 9.3
bar=donor   line=cohort median 		9.5 9.3 48.9%
4 CXCL8 12.3
bar=donor   line=cohort median 		10.3 11.4 78.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 7.3
bar=donor   line=cohort median 		6.1 6.1 91.9%
6 FCGR3B 14.0
bar=donor   line=cohort median 		14.7 14.7 9.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.7
bar=donor   line=cohort median 		14.4 14.3 81.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.3
bar=donor   line=cohort median 		10.3 10.4 37.5%
9 CD3E 11.8
bar=donor   line=cohort median 		11.9 12.0 17.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		10.9 10.9 48.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.4
bar=donor   line=cohort median 		11.5 11.7 22.4%
12 GNLY 12.4
bar=donor   line=cohort median 		12.0 12.1 72.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 26.7%
17 MT-CO2 15.2
bar=donor   line=cohort median 		15.3 15.3 33.2%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.2 15.2 69.4%
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